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ZIRC
ZFIN ID: ZDB-FIG-120214-4
Malicki et al., 1996 - Mutations affecting development of the zebrafish retina. Development (Cambridge, England)   123:263-273
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Protruding-mouth to Day 5

Fig. 6

Examples of mutant phenotypes from the categories of Growth retardation and Nonspecific retinal degeneration. Mutant individuals (lower) are shown next to their wild-type siblings (upper). (A,B,C) out of sight (out)m233. (D,E,F) turbulent (tub)m125. (G,H,I) zimny (zny)m419. (A,B) The eye of outm233 is substantially reduced at 3 dpf. (C) All retinal laminae are present and cell death in excess of wild-type levels is not observed in outm233 at this stage. At 5 dpf mutants tubm125 (D,E) and znym419(G,H) are characterized by a reduced eye size and somewhat abnormal brain shape. Cell death is extensive in both tubm125 (F) and znym419(I) retinae at 3 dpf. Cell corpses appear as small, round, intensely staining particles (F). Retinal patterning defects are inconsistent in this group of mutants. A, D and G show lateral views; B, E and H dorsal views. The dorsal side is oriented up in panels showing lateral views or sections. In panels showing head phenotypes anterior is left. All sections are transverse.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
gdf6am233/m233(AB) standard conditions Protruding-mouth brain decreased size, abnormal
Protruding-mouth brain decreased width, abnormal
Protruding-mouth eye decreased size, abnormal
Day 5 eye decreased size, abnormal
Day 5 pigmentation process quality, abnormal
Day 5 retina layer formation process quality, normal
turbulentm125/m125(AB) standard conditions Protruding-mouth brain decreased size, abnormal
Protruding-mouth brain shape, abnormal
Protruding-mouth eye decreased size, abnormal
Protruding-mouth retina degenerate, abnormal
Day 5 eye decreased size, abnormal
Day 5 retina apoptotic, abnormal
Day 5 retinal inner plexiform layer morphology, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
znym419/m419(AB) standard conditions Protruding-mouth brain decreased size, abnormal
Protruding-mouth brain shape, abnormal
Protruding-mouth eye decreased size, abnormal
Protruding-mouth retina degenerate, abnormal
Day 5 eye decreased size, abnormal
Day 5 retina apoptotic, abnormal
Day 5 retinal inner plexiform layer morphology, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright.