FIGURE

Fig. 6

ID

ZDB-FIG-120214-4

Publication

Malicki et al., 1996 - Mutations affecting development of the zebrafish retina

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Fig. 6

Examples of mutant phenotypes from the categories of Growth retardation and Nonspecific retinal degeneration. Mutant individuals (lower) are shown next to their wild-type siblings (upper). (A,B,C) out of sight (out)^m233. (D,E,F) turbulent (tub)^m125. (G,H,I) zimny (zny)^m419. (A,B) The eye of out^m233 is substantially reduced at 3 dpf. (C) All retinal laminae are present and cell death in excess of wild-type levels is not observed in out^m233 at this stage. At 5 dpf mutants tub^m125 (D,E) and zny^m419(G,H) are characterized by a reduced eye size and somewhat abnormal brain shape. Cell death is extensive in both tub^m125 (F) and zny^m419(I) retinae at 3 dpf. Cell corpses appear as small, round, intensely staining particles (F). Retinal patterning defects are inconsistent in this group of mutants. A, D and G show lateral views; B, E and H dorsal views. The dorsal side is oriented up in panels showing lateral views or sections. In panels showing head phenotypes anterior is left. All sections are transverse.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gdf6a^m233/m233 (AB) turbulent^m125/m125 (AB) zny^m419/m419 (AB)
Observed In:	brain eye pigmentation retina retina layer formation retinal inner plexiform layer retinal outer plexiform layer
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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