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ZFIN ID: ZDB-FIG-120214-3
Malicki et al., 1996 - Mutations affecting development of the zebrafish retina. Development (Cambridge, England)   123:263-273
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Protruding-mouth to Day 5

Fig. 5

Phenotypes of mutations predominantly affecting development of the outer retina analyzed on histological sections (A) In mikre oko (mok)m632, a poorly differentiated photoreceptor cell layer is present in the central retina at 3 dpf. The presumptive photoreceptor cells frequently do not display the wild-type, elongated shape. (B) At 5 dpf, the photoreceptor cell layer is absent in mokm632. (C) The elipsa (eli)m649 retina at 3 dpf. Excessive cell death is most obvious in the central portion of the photoreceptor cell layer (arrowhead in C). (D) At 5 dpf most of the photoreceptor cells in elim649 are absent. Some cells survive in the periphery of the photoreceptor cell layer (arrowheads in D). (E) The krenty (krt)m699 retina at 3 dpf. The photoreceptor cell layer is discontinuous (arrowhead in E). Gaps in the array of photoreceptor cells appear to be filled with cells originating from the inner nuclear layer. This pattern persists till 5 dpf (F). (G) Retina of niezerka (nie)m743 at 5 dpf. The photoreceptor cell layer is missing. (H) brudas (bru)m148 retina at 3 dpf. As in elim649 some morphologically normal photoreceptors are present in the periphery (arrowhead in H). All sections are transverse. In all panels ventral is down.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
brum148/m148(AB) standard conditions Protruding-mouth eye photoreceptor cell decreased amount, abnormal
Protruding-mouth retinal photoreceptor layer structure, abnormal
dctn1am632/m632(AB) standard conditions Protruding-mouth eye photoreceptor cell shape, abnormal
Protruding-mouth retinal photoreceptor layer poorly differentiated, abnormal
Day 5 retinal photoreceptor layer absent, abnormal
krtm699/m699(AB) standard conditions Protruding-mouth retinal inner nuclear layer neuron displaced to retinal photoreceptor layer, abnormal
Protruding-mouth retinal photoreceptor layer structure, abnormal
Day 5 retinal inner nuclear layer neuron displaced to retinal photoreceptor layer, abnormal
Day 5 retinal photoreceptor layer structure, abnormal
niem743/m743(AB) standard conditions Day 5 retinal photoreceptor layer absent, abnormal
traf3ip1m649/m649(AB) standard conditions Protruding-mouth retinal photoreceptor layer apoptotic, abnormal
Day 5 eye photoreceptor cell decreased amount, abnormal
Day 5 retinal photoreceptor layer structure, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright.