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ZIRC
ZFIN ID: ZDB-FIG-091117-7
Malicki et al., 1996 - Mutations affecting development of the zebrafish retina. Development (Cambridge, England)   123:263-273
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Pec-fin to Protruding-mouth

Fig. 3

Transverse sections of mutant retinae at 3 dpf. The phenotypes of (A) oko meduzy (ome)m98, (B) glass onion (glo)m117 and (C) nagie oko (nok)m227 mutants are similar to each other. In the retinae of these mutants the plexiform matter forms patches instead of laminae. omem98 and nokm227 form a well differentiated optic nerves (arrowhead in A). (D) Retina of heart and soul (has)m129 mutant at 60 hpf. Although the optic nerve is present, the retina of hasm129 does not develop stratification. (E) one eyed pinhead (oep)m134, (F) cyclops (cyc)b16 and (G) bozozok (boz)m168 develop cyclopia. In these mutants retinal stratification develops to a limited degree. Abnormalities of the neuronal patterning are usually associated with presence of numerous cell corpses. (H) Some pandora (pan)m313 mutants develop normal neuronal lamination. The portion of the retina ventral to the optic nerve (arrowhead in H) is absent in panm313. In all panels ventral is down.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
cdh2m117/m117(AB) standard conditions Protruding-mouth retina layer formation disrupted, abnormal
Protruding-mouth retinal inner plexiform layer patchy, abnormal
Protruding-mouth retinal neural layer disorganized, abnormal
Protruding-mouth retinal outer plexiform layer patchy, abnormal
crb2am98/m98(AB) standard conditions Protruding-mouth retina apoptotic, abnormal
Protruding-mouth retina layer formation disrupted, abnormal
Protruding-mouth retinal inner plexiform layer patchy, abnormal
Protruding-mouth retinal neural layer disorganized, abnormal
Protruding-mouth retinal outer plexiform layer patchy, abnormal
dharmam168/m168(AB) standard conditions Protruding-mouth eye fused with eye, abnormal
Protruding-mouth retina apoptotic, abnormal
Protruding-mouth retina stratification, abnormal
Protruding-mouth retina layer formation disrupted, abnormal
mpp5am227/m227(AB) standard conditions Protruding-mouth retina layer formation disrupted, abnormal
Protruding-mouth retinal inner plexiform layer patchy, abnormal
Protruding-mouth retinal neural layer disorganized, abnormal
Protruding-mouth retinal outer plexiform layer patchy, abnormal
ndr2Df(Chr12:hhex)b16/b16 standard conditions Protruding-mouth eye fused with eye, abnormal
Protruding-mouth retina stratification, abnormal
Protruding-mouth retina layer formation disrupted, abnormal
prkcim129/m129(AB) standard conditions Pec-fin retina unstratified, abnormal
Pec-fin retina layer formation arrested, abnormal
supt6hm313/m313(AB) standard conditions Protruding-mouth retina ventral region aplastic, abnormal
tdgf1m134/m134(AB) standard conditions Protruding-mouth eye fused with eye, abnormal
Protruding-mouth retina stratification, abnormal
Protruding-mouth retina layer formation disrupted, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright.