FIGURE

Fig. S4

ID

ZDB-FIG-120202-54

Publication

Dohn et al., 2012 - Distinct phases of Wnt/β-catenin signaling direct cardiomyocyte formation in zebrafish

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Fig. S4

Decreased Wnt signaling at the sphere and shield stages results in dorsalization of embryos. (A,C,E,G,I,K) HCSEs. (B,D,F,H,J,L) Embryos with decreased Wnt signaling at the designated stages. By 80% epiboly, aldh1a2 is expressed in the dorso-lateral region, while it is excluded from the dorsal and ventral regions. Tbx6 and flh expression is excluded from the dorsal region and in the dorsal region respectively at 80% epiboly. (B,F,J) Embryos with decreased Wnt signaling at the sphere stage are severely dorsalized, as indicated by the expansion of dorso-lateral aldh1a2 expression around the ventral margin and the expanded dorsal region (compare arrows in A to B, in E to F, and in I to J). (D,H,L) Embryos with decreased Wnt signaling at the shield stage are modestly dorsalized. The dorsal region is marginally expanded (upper arrows in C,D,G,H,K,L) and the ventral region is marginally reduced (lower arrows in C and D). All images are vegetal views with dorsal up.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

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Acknowledgments

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Reprinted from Developmental Biology, 361(2), Dohn, T.E., and Waxman, J.S., Distinct phases of Wnt/β-catenin signaling direct cardiomyocyte formation in zebrafish, 364-76, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.