FIGURE

Fig. 1

ID

ZDB-FIG-120202-42

Publication

Dohn et al., 2012 - Distinct phases of Wnt/β-catenin signaling direct cardiomyocyte formation in zebrafish

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Fig. 1

Effects of increased Wnt signaling on CM differentiation markers. (A–F) myl7, (G–L) vmhc and (M–R) amhc expression in representative HCSEs and embryos when Wnt signaling is increased using the Tg(hsp70l:wnt8a-GFP)^w34 line at the designated stages. Increased Wnt signaling promoted (B,H,N) and then inhibited (C–E,I–K,O–Q) the expression of CM differentiation markers when Wnt signaling was increased prior to gastrulation at the sphere (SP) stage and from the initiation of gastrulation [shield (SH)] through early somitogenesis. (F,L,R) Increasing Wnt signaling at 16 s does not overtly affect CM differentiation markers. (S) Graph indicating the fold difference in areas of cardiac differentiation marker expression. Asterisks indicate a statistical difference in the areas from HCSEs and GFP + embryos in Supplemental Table 1 according to Student′s t-test. Images in all figures are dorsal views with anterior up, unless otherwise indicated.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 361(2), Dohn, T.E., and Waxman, J.S., Distinct phases of Wnt/β-catenin signaling direct cardiomyocyte formation in zebrafish, 364-76, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.