FIGURE

Fig. 5

ID

ZDB-FIG-110621-13

Publication

Langenbacher et al., 2011 - The PAF1 complex differentially regulates cardiomyocyte specification

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Fig. 5

Fig. 5. The PAF1C is required for the specification of cardiomyocytes from the anterior lateral plate mesoderm. (A–L) Dorsal views of hand2 (A–C), gata4 (D–F), gata5 (G–I), and tbx20 (J–L) expression in 16S stage wild type and morphant embryos. In wild type embryos, expression of hand2 (A), gata4 (D), and gata5 (G) is detected in the anterior lateral plate mesoderm. In ctr9 and rtf1 morphants, hand2 (B and C), gata4 (E and F), and gata5 (H and I) are expressed in a domain similar to that of wild type embryos. (J–L) In wild type embryos, tbx20 is expressed by cardiomyocyte progenitors in the ALPM (J). Expression of tbx20 is reduced in ctr9 morphants (K) and strongly reduced in rtf1 morphants (L) at the 16S stage.

Expression Data

Genes:	gata4 gata5 hand2 tbx20
Fish:	WT WT + MO1-ctr9 WT + MO1-rtf1
Knockdown Reagents:	MO1-ctr9 MO1-rtf1
Anatomical Terms:	anterior lateral plate mesoderm anterior lateral plate mesoderm cardiac muscle myoblast
Stage:	14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-ctr9 WT + MO1-rtf1
Knockdown Reagents:	MO1-ctr9 MO1-rtf1
Observed In:	cardiac cell fate specification
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 353(1), Langenbacher, A.D., Nguyen, C.T., Cavanaugh, A.M., Huang, J., Lu, F., and Chen, J.N., The PAF1 complex differentially regulates cardiomyocyte specification, 19-28, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.