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General Information
ZFIN ID: ZDB-FIG-110408-9
Corti et al., 2011 - Interaction between alk1 and blood flow in the development of arteriovenous malformations. Development (Cambridge, England)   138(8):1573-1582 Full text @ Development
Anatomical Term:
Stage: Prim-25

Fig. S5

The first aortic arch is alk1 positive and abnormal in alk1 mutants. (A-C) In situ hybridization showing alk1 (A) and edn1 (B,C) expression in 36 hpf wild-type (A,B) and alk1-/- embryos. alk1 is expressed in the first aortic arch at 36 hpf (A, arrow). edn1 is expressed in the first aortic arch in wild-type embryos (B, arrow) but expression is lost in alk1 mutants (C). (D,E) Two-dimensional projections of confocal z-series 36 hpf Tg(fli1a:nEGFP)y7 embryos. The first aortic arch is enlarged in alk1 mutants (E) compared with wild-type siblings (D). However, at this early time, differences are not yet statistically significant (F). Data in F represent an average of three systolic diameters per embryo measured from high speed confocal micrographs, meanĀ±s.e.m. n=8 wild type; n=5 alk1-/-. (A,D,E) Lateral views, anterior leftwards. (A,D) left side. (E) right side. (B,C) dorsal view, anterior leftwards. Scale bars: 50 μm.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
acvrl1 WT standard conditions Prim-25 aortic arch 1 ISH
edn1 WT standard conditions Prim-25 aortic arch 1 ISH
acvrl1y6/y6 standard conditions Prim-25 Not Detected aortic arch 1 ISH
Antibody Labeling Details No data available
Phenotype Details No data available
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development