ZFIN is now using GRCz12tu for Genomic Data
Gene
edn1
- ID
- ZDB-GENE-000920-1
- Name
- endothelin 1
- Symbol
- edn1 Nomenclature History
- Previous Names
-
- et-1
- et1
- fb14d01
- suc
- sucker
- wu:fb14d01 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable endothelin A receptor binding activity; endothelin B receptor binding activity; and hormone activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cell differentiation; and positive regulation of protein secretion. Acts upstream of or within several processes, including anterior lateral line neuromast development; face morphogenesis; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; ectoderm; mesoderm; neural crest; and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 55 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu115 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 43 figures from 22 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Endothelin | Endothelin-like toxin | Endothelin-like toxin, conserved site |
|---|---|---|---|---|---|
| UniProtKB:Q9I8G3 | InterPro | 188 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers