FIGURE

Fig. 3

ID
ZDB-FIG-110317-13
Publication
Osborn et al., 2011 - Cdkn1c drives muscle differentiation through a positive feedback loop with Myod
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Fig. 3

Hh causes Cdkn1c to stabilize Myod. (A). Cdkn1c mRNA is Hh-dependent in adaxial cells. Shhatbx392 or smob641 mutation or cyA treatment reduces cdkn1c mRNA. Note that loss was proportional to reduction in Hh signal (arrowheads and black bracket). Shha mRNA injection caused unilateral somitic cdkn1c up-regulation (red bracket). (B,C). Cdkn1c 5′ MO injection into embryos from a shhatbx392/+ incross reduced adaxial myog mRNA (B), Myod or MyHC proteins (C). Note the delay in myog mRNA and reduction in Myod protein (brackets). (D). Cdkn1c ATG MO injection reduces adaxial Myod at tailbud stage. Bar: 100 μm.

Expression Data
Genes:
Antibodies:
Fish:
Condition:
Knockdown Reagents:
Anatomical Terms:
Stage Range: Bud to Prim-5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Bud to 5-9 somites

Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 350(2), Osborn, D.P., Li, K., Hinits, Y., and Hughes, S.M., Cdkn1c drives muscle differentiation through a positive feedback loop with Myod, 464-475, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.