FIGURE

Fig. 4

ID

ZDB-FIG-101206-25

Publication

Seth et al., 2010 - Core fucosylation is required for midline patterning during zebrafish development

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Fig. 4

Patterning defects in the eye and forebrain of 27 hpf FucT8 morphant embryos. A: Ventral view of a FucT8 morphant embryo showing severe loss of islet-1 expressing retinal precursors (arrow). Ninety percent of 20 injected embryos showed this phenotype. B: Whole eyes showing a reduced number of ath-5-positive RGC precursors (arrow) in FucT8 morphant embryos. Similar to eighty-five percent of 40 injected embryos showed this phenotype. C: In situ hybridization using pax 2.1 shows that morphant embryos have a shorter and thicker optic stalk, relative to controls (arrow), and increased pax 2.1 expression in the eye field. Similar to eighty-five percent of 40 injected embryos showed this phenotype.

Expression Data

Genes:	atoh7 isl1a pax2a
Fish:	AB AB + MO1-fut8a
Knockdown Reagent:	MO1-fut8a
Anatomical Terms:	optic cup optic stalk presumptive neural retina retinal ganglion cell
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-fut8a
Knockdown Reagent:	MO1-fut8a
Observed In:	eye optic stalk retina development in camera-type eye retinal ganglion cell
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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