FIGURE

Fig. 8

ID

ZDB-FIG-101118-34

Publication

Song et al., 2010 - Neural and Synaptic Defects in slytherin, a Zebrafish Model for Human Congenital Disorders of Glycosylation

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Fig. 8

A–X. Presynaptic terminals (green) and postsynaptic AChR clusters (red) in 24 and 48 embryos from WT (A, G, M, S), srn (B, H, N, T), des (C, I, O, U), dla (D, J, P, V), mib (E, K, Q, W) and DAPT treated embryos (F, L, R, X). Boxed regions are shown at higher magnification at 24 (G–L) and 48 hpf (S–X; 3 hemisegments in each of 20 embryos, 3 carrier pairs for each). Scale bar = 20 μm. Y. Presynaptic terminal, axon and synapse area at the choice point was significantly increased in all mutants, except in mib and DAPT treated embryos at 48 hpf, compared to WT (one-way ANOVA, Bonferroni′s Multiple Comparison Test, ** p<0.01, *** p<0.001).

Expression Data

Antibody:	Ab-SV2
Fish:	WT gmds^{p31erb/p31erb} dla^hi781Tg mib1^hi904Tg notch1a^b420
Anatomical Term:	secondary motor neuron presynaptic membrane
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gmds^{p31erb/p31erb} dla^hi781Tg notch1a^b420
Observed In:	neuromuscular junction development
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

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