FIGURE

Fig. 5

ID

ZDB-FIG-101012-19

Publication

Mei et al., 2010 - Mtmr8 is essential for vasculature development in zebrafish embryos

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Fig. 5

Mtmr8 negatively regulates the PI3K/Akt pathway. (A-D) Mtmr8 expression in wild type (WT) embryo (A) and the treated embryos (C-D) with different doses of LY294002 (LY) at 26 hpf. (E-H) The corresponding amplification of A-D, showing the detailed changes in the trunk vasculature. (I) Mtmr8 expression changes revealed by Q-RT-PCR in embryos treated with different doses of LY294002 (μM). (J-L) Three phenotypes of ephrinB2a expression and quantification data (M) in 26 hpf Mtmr8 morphants (30 embryos in each experiment group). (N) Quantitative Western blot data of ERK phosphorylation in 20-somite Mtmr8 morphants. * Indicates significance of p < 0.05.

Expression Data

Genes:	efnb2a mtmr8
Fish:	AB
Condition:	chemical treatment: pharmaceutical
Anatomical Terms:	axial vasculature dorsal aorta
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB AB + MO1-mtmr8
Condition:	chemical treatment: pharmaceutical
Knockdown Reagent:	MO1-mtmr8
Observed In:	dorsal aorta MAP kinase kinase activity
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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