FIGURE

Fig. 2

ID

ZDB-FIG-101012-16

Publication

Mei et al., 2010 - Mtmr8 is essential for vasculature development in zebrafish embryos

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Fig. 2

Mtmr8 knockdown results in vascular defects. (A-D) Vascular morphology in Cont-MO (A), mtmr8-MO (B), mtmr8-MO+ mtmr8 mRNA (C) and mtmr8-MO+dnPKA mRNA Tg(kdrl:GFP)^la116 embryos at 48 hpf. The presumptive lumen of DA and PCV are indicated by red and white bars, respectively. White arrowheads point to the interruption of Se. (E, F) Longitudinal sections of trunk regions in 48 hpf corresponding embryos. (G-I) Transverse sections of trunk regions in 48 hpf corresponding embryos. Sections were stained with hematoxylin and eosin. (J) Statistical data of three different defects in three independent experiments of Cont-MO, mtmr8-MO, mtmr8-MO+mtmr8 mRNA, mtmr8-MO+mis-mtmr8 mRNA, mtmr8-MO+dnPKA mRNA, and -MO+scl mRNA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	la116Tg + MO1-mtmr8
Knockdown Reagent:	MO1-mtmr8
Observed In:	caudal vein plexus dorsal aorta dorsal longitudinal anastomotic vessel heart intersegmental vessel vasculogenesis
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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