ZFIN ID: ZDB-GENE-990415-67
Gene Name: ephrin-B2a
Gene Symbol: efnb2a    Nomenclature History

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Previous Names: efnb2, ephrin-B2a, id:ibd5072

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have ephrin receptor binding activity. Involved in several processes, including angioblast cell migration involved in selective angioblast sprouting; nervous system development; and optic vesicle morphogenesis. Predicted to localize to plasma membrane. Is expressed in several structures, including brain; germ ring; hindbrain neural keel; immature eye; and vasculature. Orthologous to human EFNB2 (ephrin B2).
Genome Resources: Alliance (1),  Gene:30219 (1),  Ensembl(GRCz11):ENSDARG00000020164 (2)
GENE EXPRESSION
All Expression Data: 191 figures from 134 publications
Directly Submitted Expression Data: 4 figures (6 images) from Kudoh et al., 2001 [ibd5072]
  7 figures (33 images) from Thisse et al., 2005 [eu689]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
efnb2a_unrecovered Point Mutation Unknown Unknown ENU
fh263 Point Mutation Unknown Unknown ENU
hu3393 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa13177 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-efnb2a N/A 7
    MO2-efnb2a N/A 6
    MO3-efnb2a N/A 1
    MO4-efnb2a N/A 1
    MO5-efnb2a N/A 2
    DISEASE ASSOCIATED WITH efnb2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH efnb2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon target recognition (more)
    Cellular Component plasma membrane (more)
    Molecular Function ephrin receptor binding (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA efnb2a-201 (1)    Ensembl 4598
    ncRNA efnb2a-002 (1)    Ensembl 534
    efnb2a-003 (1)    Ensembl 840
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-efnb2 polyclonal IgG Goat IHC, WB R&D Systems
    10
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM efnb2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(efnb2a:EGFP) efnb2a EGFP Danio rerio 1 2
    Tg(nkx2.3:efnb2a,myl7:EGFP) myl7nkx2.3 efnb2aEGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    efnb2a Contained in: [BAC] CH211-149B20 (1)
    efnb2a Encodes: [EST] eu689 (1), ibd5072, fc29f11 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131023 (1) 999 nt
    Genomic GenBank:CR391949 (1) 162252 nt
    Select Tool
    Polypeptide UniProtKB:B0CLY3 (1) 332 aa
    Sequence Information (all 21)
    ORTHOLOGY for efnb2a ( Chr: 9 )
    CITATIONS (265)