FIGURE

Fig. S1

ID

ZDB-FIG-100603-12

Publication

Zuniga et al., 2010 - Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face

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Fig. S1

Identification of the jag1b^b1105 mutation. (A) Using synteny between Fugu and zebrafish Vega and Ensembl contigs, the b1105 mutation was mapped to a small region of LG13 containing jag1b. Recombinants per 2000 meioses are shown above each contig, and positions in Mb and marker names below. (B) An electrophoretogram showing sequence surrounding the G-to-A transition that creates a premature stop codon (underlined) in jag1b^b1105 mutants (m). (C-G) Unilateral flat-mount dissections of 6 dpf facial skeletons stained for cartilage (blue) and bone (red). jag1b-MO larvae show similar skeletal defects to jag1b^b1105 mutants, including truncation of Pq (arrowheads), shape changes in Hm (arrows) and transformed Op bone (asterisks). In notch2-MO larvae, ectopic cartilage processes (red arrowheads) are seen at low frequency near the DV interfaces of the hyoid (F) and mandibular (G) skeletons.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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