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General Information
ZIRC
ZFIN ID: ZDB-FISH-150901-16069
Fish name: fgf8ati282a/ti282a
Genotype: fgf8ati282a/ti282a
Targeting Reagent: none
Current Source: Nüsslein-Volhard Lab (alive)
HUMAN DISEASE MODELED by fgf8ati282a/ti282a
No data available
GENE EXPRESSION
Gene expression in fgf8ati282a/ti282a
RNA expression
Expressed Gene Structure Conditions Figures
aldh1a2 standard conditions Fig. 11 with image from Hamade et al., 2006
aldh1a3 standard conditions Fig. 9 with image from Maier et al., 2014
aldocb control Fig. 3 with image from Jászai et al., 2003
ascl1a standard conditions Fig. 8 with image from Brand et al., 1996
ascl1b control Fig. 4 with image from Jászai et al., 2003
atoh1a standard conditions Fig. 3 with image from Maier et al., 2014
Fig. 4 with image from Foucher et al., 2006
Fig. 3 with image from Jászai et al., 2003
barx1 standard conditions Fig. 8 with image from Sperber et al., 2008
calb2b control Fig. 2 with image from Kapsimali et al., 2011
cldna standard conditions Fig. 2 with image from Kwon et al., 2009
cnpy1 standard conditions Fig. 1 from Hirate et al., 2006
cntn2 control Fig. 3 with image from Jászai et al., 2003
col2a1a control Fig. 5 with image from McCarthy et al., 2016
cyp26a1 standard conditions Fig. 11 with image from Hamade et al., 2006
dlx2a standard conditions Fig. 2 with image from Albertson et al., 2005
Fig. 6 with image from Crump et al., 2004
text only from Shanmugalingam et al., 2000
dlx3b standard conditions Fig. 4 with image from Mackereth et al., 2005
dmbx1a control Fig. 2 with image from Jászai et al., 2003
dusp6 standard conditions text only from Tsang et al., 2004
efna5a standard conditions Fig. 11 with image from McMahon et al., 2009
Fig. 1 with image from Picker et al., 2009
Fig. 3 with image from Picker et al., 2005
egr2b standard conditions Fig. 6 with image from Crump et al., 2004
text only from Wiellette et al., 2004
emx3 standard conditions text only from Shanmugalingam et al., 2000
en1a standard conditions Fig. 11 with image from Reifers et al., 1998
en2a standard conditions Fig. 2 from Knight et al., 2008
Fig. 8 with imageFig. 10 with image from Reifers et al., 1998
epha4a standard conditions text only from Teraoka et al., 2004
Fig. 4 with image from Jászai et al., 2003
text only from Durbin et al., 2000
epha4b standard conditions Fig. 11 with image from McMahon et al., 2009
Fig. 1 with image from Picker et al., 2009
Fig. 3 with image from Picker et al., 2005
etv4 standard conditions Fig. S2 with image from Foucher et al., 2006
etv5b standard conditions Fig. 6 with image from Foucher et al., 2006
text only from Scholpp et al., 2004
eya1 standard conditions Fig. 5 with image from Nechiporuk et al., 2007
fgf3 standard conditions Fig. S1 with image from Foucher et al., 2006
fgf8a standard conditions Fig. 6Fig. 7 from Guo et al., 1999
Fig. 5Fig. 11 with image from Reifers et al., 1998
fgfr3 standard conditions text only from Tallafuss et al., 2003
foxa2 standard conditions Fig. 6 with image from Crump et al., 2004
foxd5 standard conditions Fig. 5 with image from Lee et al., 2009
foxg1a standard conditions Fig. 3 with image from Picker et al., 2005
foxi1 standard conditions Fig. 5 with image from Nechiporuk et al., 2007
gap43 control Fig. 3 with image from Jászai et al., 2003
gata4 standard conditions Fig. 3 with image from Reifers et al., 2000
gata6 standard conditions Fig. 3 with image from Reifers et al., 2000
gbx2 standard conditions Fig. 7 with image from Foucher et al., 2006
text only from Reim et al., 2002
gnrh2 standard conditions Fig. 3 with image from Whitlock et al., 2005
grem1a standard conditions Fig. 7 with image from Nicoli et al., 2005
has2 control Fig. 7 with imageFig. 8 with image from McCarthy et al., 2016
chemical treatment: SU5402 Fig. 8 with image from McCarthy et al., 2016
her5 standard conditions text only from Tallafuss et al., 2003
Fig. 8 with image from Reifers et al., 1998
her11 standard conditions Fig. 3 with image from Ninkovic et al., 2005
hesx1 standard conditions text only from Shanmugalingam et al., 2000
hhex standard conditions Fig. 6 with image from Wendl et al., 2007
hmx3a standard conditions Fig. 3 from Adamska et al., 2000
ier2a standard conditions Fig. S3 with image from Hong et al., 2009
irx1b standard conditions Fig. S3 with image from Foucher et al., 2006
irx2a standard conditions Fig. S3 with image from Foucher et al., 2006
kdrl standard conditions Fig. 1 with image from Reifers et al., 2000
lhx1a standard conditions text only from Shanmugalingam et al., 2000
lhx1b standard conditions text only from Shanmugalingam et al., 2000
lmo4a standard conditions Fig. 4 with image from Lane et al., 2002
ltbp3 standard conditions Fig. S1 with image from Zeng et al., 2014
mafba standard conditions text only from Wiellette et al., 2004
mdkb standard conditions Fig. 6 with image from Winkler et al., 2001
mef2cb standard conditions Fig. S1 with image from Zeng et al., 2014
mespaa standard conditions Fig. 7 with image from Lee et al., 2009
mespba standard conditions Fig. 7 with image from Lee et al., 2009
myf5 standard conditions Fig. 3 with image from Groves et al., 2005
myh6 standard conditions Fig. 2 with image from Marques et al., 2008
myh7 standard conditions Fig. 2 with image from Marques et al., 2008
myhz1.1 standard conditions text only from Mathieu et al., 2004
myl7 standard conditions Fig. S2 from Keegan et al., 2005
mylpfa standard conditions Fig. 2 with image from Groves et al., 2005
myod1 standard conditions Fig. 5 with image from Kok et al., 2010
Fig. 5 from Ochi et al., 2008
Fig. 5 with image from Plaster et al., 2007
Fig. 10 with imageFig. 11 with image from Hamade et al., 2006
Fig. 3 with image from Groves et al., 2005
text only from Mathieu et al., 2004
Fig. 10 with image from Reifers et al., 1998
chemical treatment by environment: 4-(diethylamino)benzaldehyde Fig. 10 with image from Hamade et al., 2006
neurod1 control Fig. 3 with image from Jászai et al., 2003
neurog1 standard conditions Fig. 5 with image from Nechiporuk et al., 2007
nkx2.1 standard conditions text only from Shanmugalingam et al., 2000
nkx2.3 standard conditions Fig. 2 with image from Albertson et al., 2005
nkx2.4b standard conditions Fig. 6 with image from Wendl et al., 2007
nkx2.5 standard conditions Fig. 3 with image from Reifers et al., 2000
nkx2.7 standard conditions Fig. 6 with image from Crump et al., 2004
Fig. 3 with image from Reifers et al., 2000
noto standard conditions Fig. 3 with image from Mann et al., 2007
ntn1b standard conditions text only from Shanmugalingam et al., 2000
otpb standard conditions Fig. 7 with imageFig. 9 with image from Del Giacco et al., 2006
otx2b standard conditions Fig. 7 with image from Foucher et al., 2006
Fig. 2 with imageFig. 4 with image from Jászai et al., 2003
text only from Tallafuss et al., 2003
pax2a standard conditions 13 figures with image from 11 publications
pax3a standard conditions Fig. 5 with image from Hammond et al., 2007
pax6a standard conditions Fig. 5 with image from Foucher et al., 2006
text only from Tallafuss et al., 2003
pax7a standard conditions Fig. 5 with image from Hammond et al., 2007
pax8 standard conditions Fig. 2 with image from Kwon et al., 2009
Fig. 5 with image from Hans et al., 2007
Fig. 4 with image from Mackereth et al., 2005
Fig. 1 with image from Jászai et al., 2003
chemical treatment by environment: 4-(diethylamino)benzaldehyde Fig. 5 with image from Hans et al., 2007
pcdh8 standard conditions Fig. 5 with imageFig. 8 with image from Plaster et al., 2007
chemical treatment: trichostatin A Fig. 8 with image from Plaster et al., 2007
phox2a standard conditions Fig. 6 from Guo et al., 1999
phox2bb standard conditions Fig. 5 with image from Nechiporuk et al., 2007
pitx2 standard conditions Fig. 1 with image from Albertson et al., 2005
reln standard conditions Fig. 5 with image from Foucher et al., 2006
sall1a control Fig. 1 with image from Jászai et al., 2003
sema3d standard conditions text only from Shanmugalingam et al., 2000
shha standard conditions text only from Shanmugalingam et al., 2000
Fig. 11 with image from Reifers et al., 1998
shhb standard conditions Fig. 4 with image from Jászai et al., 2003
text only from Shanmugalingam et al., 2000
six3a standard conditions text only from Shanmugalingam et al., 2000
smarcd3b standard conditions Fig. 3 from Ochi et al., 2008
snai1a standard conditions Fig. 10 with image from Reifers et al., 1998
sox2 standard conditions Fig. 3 with image from Maier et al., 2014
sox3 standard conditions Fig. 2 with image from Nikaido et al., 2007
sox9a control Fig. 5 with image from McCarthy et al., 2016
spaw standard conditions Fig. 1 with image from Albertson et al., 2005
spry1 standard conditions Fig. 6 with image from Komisarczuk et al., 2008
spry2 standard conditions Fig. 3 from Ochi et al., 2008
spry4 standard conditions Fig. S2 with image from Foucher et al., 2006
Fig. 5 with image from Picker et al., 2005
Fig. 1 with image from Jászai et al., 2003
stm control Fig. 5 with image from Hans et al., 2007
chemical treatment by environment: 4-(diethylamino)benzaldehyde Fig. 5 with image from Hans et al., 2007
tbx5a standard conditions Fig. 11 with image from McMahon et al., 2009
Fig. 3 with image from Picker et al., 2005
tbxta standard conditions Fig. 5 with image from Plaster et al., 2007
Fig. 1 with image from Albertson et al., 2005
tecta standard conditions Fig. 3 with image from Maier et al., 2014
th standard conditions text only from Holzschuh et al., 2003
Fig. 4 with image from Jászai et al., 2003
Fig. 6 from Guo et al., 1999
tph2 standard conditions text only from Teraoka et al., 2004
vax2 standard conditions Fig. 3 with image from Picker et al., 2005
wnt1 standard conditions text only from Tallafuss et al., 2003
Fig. 8 with image from Brand et al., 1996
wnt4 control Fig. 2 with image from Jászai et al., 2003
Reporter gene expression No data available
PHENOTYPE
Phenotype in fgf8ati282a/ti282a
Phenotype Conditions Figures
alar plate midbrain region morphology, abnormal control Fig. 2 with image from Jászai et al., 2003
anatomical system quality, abnormal standard conditions Fig. for (ti282a) with image from Phenotype Annotation (1994-2006)
anterior cardinal vein absent, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
apoptotic process increased occurrence, abnormal standard conditions Fig. 5 with image from Jászai et al., 2003
apoptotic process occurrence, normal standard conditions Fig. 5 with image from Jászai et al., 2003
blood circulation decreased functionality, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
blood circulation disrupted, abnormal standard conditions Fig. 1 with image from Brand et al., 1996
blood vessel organization quality, normal standard conditions Fig. 1 with image from Reifers et al., 2000
blood vessel development process quality, normal standard conditions Fig. 1 with image from Reifers et al., 2000
blood vessel endothelial cell present, normal standard conditions Fig. 1 with image from Reifers et al., 2000
brain quality, abnormal standard conditions Fig. for (ti282a) with image from Phenotype Annotation (1994-2006)
brain vasculature dorsal region absent, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
cardiac ventricle decreased length, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
cardiac ventricle hypotrophic, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
cartilage development disrupted, abnormal standard conditions Fig. 8 with image from Sperber et al., 2008
cell population proliferation occurrence, normal standard conditions Fig. 5 with image from Jászai et al., 2003
cell proliferation in hindbrain disrupted, abnormal standard conditions Fig. 5 with image from Jászai et al., 2003
cell proliferation in midbrain disrupted, abnormal standard conditions Fig. 5 with image from Jászai et al., 2003
central nervous system development disrupted, abnormal standard conditions Fig. 6 with image from Komisarczuk et al., 2008
ceratobranchial cartilage decreased amount, abnormal standard conditions Fig. 4 with image from Choe et al., 2014
cerebellum absent, abnormal standard conditions Fig. 1 with imageFig. 7 with image from Brand et al., 1996
cerebellum aplastic, abnormal standard conditions Fig. 9 with image from Heisenberg et al., 1999
Fig. 8 with image from Brand et al., 1996
cerebellum morphology, abnormal control Fig. 3 with image from Jászai et al., 2003
cerebellum development decreased process quality, abnormal standard conditions Fig. 7 with image from Reifers et al., 1998
cerebellum development disrupted, abnormal standard conditions Fig. 1 with imageFig. 3 with image from Jászai et al., 2003
determination of left/right symmetry disrupted, abnormal standard conditions Fig. 8 with image from Sperber et al., 2008
embryonic pectoral fin morphogenesis process quality, normal standard conditions Fig. 11 with image from Reifers et al., 1998
embryonic retina morphogenesis in camera-type eye decreased process quality, abnormal standard conditions Fig. 1 with image from Picker et al., 2009
embryonic viscerocranium morphogenesis disrupted, abnormal chemical treatment: dorsomorphin Fig. 9 with image from Lovely et al., 2016
embryonic viscerocranium morphogenesis process quality, normal control Fig. 9 with image from Lovely et al., 2016
endocardium present, normal standard conditions Fig. 1 with image from Reifers et al., 2000
fibroblast growth factor receptor signaling pathway process quality, abnormal control Fig. 2 with image from Kapsimali et al., 2011
forebrain neuron normal amount, normal standard conditions Fig. 6 from Lam et al., 2003
forebrain neuron spatial pattern, normal standard conditions Fig. 6 from Lam et al., 2003
heart decreased length, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
heart dysplastic, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
heart morphology, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
heart development process quality, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
heart rudiment decreased size, abnormal standard conditions Fig. 2 with image from Marques et al., 2008
hindbrain apoptotic, abnormal standard conditions Fig. 5 with image from Jászai et al., 2003
hindbrain blood vessel absent, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
inner ear decreased size, abnormal standard conditions Fig. 7 with image from Brand et al., 1996
Table 3 from Whitfield et al., 1996
inner ear has fewer parts of type otolith, abnormal standard conditions Table 3 from Whitfield et al., 1996
inner ear quality, abnormal standard conditions Fig. for (ti282a) with image from Phenotype Annotation (1994-2006)
intermediate mesoderm differentiated, normal standard conditions Fig. 10 with image from Reifers et al., 1998
intersegmental vessel absent, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
locus ceruleus development disrupted, abnormal standard conditions Fig. 6 from Guo et al., 1999
locus coeruleus absent, abnormal standard conditions Fig. 6 from Guo et al., 1999
locus coeruleus aplastic, abnormal control Fig. 4 with image from Jászai et al., 2003
locus coeruleus neuron decreased amount, abnormal standard conditions Fig. 6 from Lam et al., 2003
mesoderm anterior region has2 expression absent, abnormal chemical treatment: SU5402 Fig. 8 with image from McCarthy et al., 2016
midbrain morphology, abnormal control Fig. 2 with image from Jászai et al., 2003
midbrain quality, abnormal standard conditions Fig. for (ti282a) with image from Phenotype Annotation (1994-2006)
midbrain hindbrain boundary absent, abnormal standard conditions Fig. 1 with imageFig. 7 with image from Brand et al., 1996
midbrain hindbrain boundary aplastic, abnormal standard conditions Fig. 1 with imageFig. 3 with imageFig. 4 with image from Jászai et al., 2003
Fig. 8 with image from Brand et al., 1996
midbrain hindbrain boundary morphology, abnormal standard conditions Fig. 5 with image from Nechiporuk et al., 2007
midbrain hindbrain boundary physical object quality, abnormal standard conditions Fig. 8 with image from Reifers et al., 1998
midbrain hindbrain boundary quality, abnormal standard conditions Fig. for (ti282a) with image from Phenotype Annotation (1994-2006)
midbrain hindbrain boundary blood vessel absent, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
midbrain hindbrain boundary neural rod morphology, abnormal control Fig. 1 with imageFig. 2 with image from Jászai et al., 2003
midbrain neural rod increased thickness, abnormal standard conditions Fig. 7 with image from Brand et al., 1996
midbrain neural rod morphology, abnormal control Fig. 2 with image from Jászai et al., 2003
midbrain neural rod prominent, abnormal standard conditions Fig. 7 with image from Brand et al., 1996
midbrain-hindbrain boundary development decreased process quality, abnormal standard conditions Fig. 7 with imageFig. 8 with image from Reifers et al., 1998
midbrain-hindbrain boundary development disrupted, abnormal standard conditions Fig. 5 with image from Nechiporuk et al., 2007
Fig. 1 with imageFig. 2 with imageFig. 3 with imageFig. 4 with image from Jászai et al., 2003
myocardium present, normal standard conditions Fig. 1 with image from Reifers et al., 2000
nervous system quality, abnormal standard conditions Fig. for (ti282a) with image from Phenotype Annotation (1994-2006)
neurocranium posterior region absent, abnormal chemical treatment: SU5402 Fig. 8 with image from McCarthy et al., 2016
optic cup physical object quality, abnormal standard conditions Fig. 1 with image from Picker et al., 2009
optic tectum apoptotic, abnormal standard conditions Fig. 5 with image from Jászai et al., 2003
optic tectum increased size, abnormal standard conditions Fig. 1 with image from Jászai et al., 2003
Fig. 1 with imageFig. 7 with imageFig. 8 with image from Brand et al., 1996
optic tectum blood vessel absent, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
oral epithelium has fewer parts of type taste bud, abnormal control Fig. 2 with image from Kapsimali et al., 2011
otic placode physical object quality, abnormal standard conditions Fig. 4 with image from Mackereth et al., 2005
otic placode formation process quality, abnormal standard conditions Fig. 2 with image from Kwon et al., 2009
otic vesicle agenesis, abnormal chemical treatment: SB 431542 Fig. 1 with image from Kwon et al., 2009
otic vesicle hmx3a expression decreased amount, abnormal standard conditions Fig. 3 from Adamska et al., 2000
otic vesicle decreased size, abnormal standard conditions Fig. 3 with image from Maier et al., 2014
Fig. 1 with image from Kwon et al., 2009
Fig. 5 with image from Hans et al., 2007
Fig. 4 with imageFig. 7 with image from Mackereth et al., 2005
otic vesicle has fewer parts of type otolith, abnormal standard conditions Fig. 7 with image from Mackereth et al., 2005
otic vesicle malformed, abnormal standard conditions Fig. 1 with image from Kwon et al., 2009
otic vesicle formation process quality, abnormal chemical treatment: SB 431542 Fig. 1 with image from Kwon et al., 2009
otic vesicle morphogenesis process quality, abnormal standard conditions Fig. 4 with imageFig. 7 with image from Mackereth et al., 2005
otolith organ has fewer parts of type otolith, abnormal standard conditions Fig. 7 with image from Brand et al., 1996
pectoral fin bud morphology, normal standard conditions Fig. 11 with image from Reifers et al., 1998
pharyngeal arch morphology, abnormal standard conditions Fig. 4 with image from Plaster et al., 2007
pharyngeal arch blood vessel absent, abnormal standard conditions Fig. 1 with image from Reifers et al., 2000
pharyngeal arch 3-7 morphology, abnormal standard conditions Fig. 8 with image from Sperber et al., 2008
pharyngeal arch 3-7 skeleton disorganized, abnormal standard conditions Fig. 4 with image from Plaster et al., 2007
pharyngeal arch 3-7 skeleton quality, abnormal standard conditions Fig. for (ti282a) with image from Phenotype Annotation (1994-2006)
pharyngeal arch cartilage morphology, abnormal chemical treatment: dorsomorphin Fig. 9 with image from Lovely et al., 2016
pharyngeal pouch decreased amount, abnormal standard conditions Fig. 4 with image from Choe et al., 2014
post-vent region curved ventral, abnormal standard conditions Table 1 from Brand et al., 1996
post-vent region morphology, normal standard conditions Fig. 5 with image from Plaster et al., 2007
post-vent region mesoderm morphology, abnormal chemical treatment: trichostatin A Fig. 8 with image from Plaster et al., 2007
post-vent region mesoderm morphology, normal standard conditions Fig. 5 with image from Plaster et al., 2007
posterior macula decreased size, abnormal standard conditions Fig. 3 with image from Maier et al., 2014
posterior macula has fewer parts of type hair cell, abnormal standard conditions Fig. 3 with image from Maier et al., 2014
retina development in camera-type eye disrupted, abnormal standard conditions Fig. 11 with image from McMahon et al., 2009
retinal ganglion cell axon guidance disrupted, abnormal standard conditions Table 1 from Brand et al., 1996
rhombomere 1 morphology, abnormal control Fig. 4 with image from Jászai et al., 2003
rhombomere 3 decreased thickness, abnormal control Fig. 4 with image from Jászai et al., 2003
rhombomere 5 decreased thickness, abnormal control Fig. 4 with image from Jászai et al., 2003
rostrocaudal neural tube patterning disrupted, abnormal control Fig. 4 with image from Jászai et al., 2003
segmental plate decreased size, abnormal chemical treatment: trichostatin A Fig. 8 with image from Plaster et al., 2007
semicircular canal truncated, abnormal standard conditions Fig. 7 with image from Brand et al., 1996
sensory system quality, abnormal standard conditions Fig. for (ti282a) with image from Phenotype Annotation (1994-2006)
somite poorly differentiated, abnormal standard conditions Fig. 10 with image from Reifers et al., 1998
somite size, normal control Fig. 4 with image from Kok et al., 2010
somite development decreased process quality, abnormal standard conditions Fig. 10 with image from Reifers et al., 1998
statoacoustic (VIII) ganglion hmx3a expression absent, abnormal standard conditions Fig. 3 from Adamska et al., 2000
taste bud formation decreased process quality, abnormal control Fig. 2 with image from Kapsimali et al., 2011
tegmentum morphology, abnormal standard conditions Fig. 8 with image from Brand et al., 1996
thyroid primordium decreased size, abnormal standard conditions Fig. 6 with image from Wendl et al., 2007
whole organism lacks all parts of type midbrain hindbrain boundary, abnormal standard conditions Fig. 7 with image from Reifers et al., 1998
whole organism lacks all parts of type cerebellum, abnormal standard conditions Fig. 7 with image from Reifers et al., 1998
whole organism lethal (sensu genetics), abnormal standard conditions Fig. for (ti282a) with image from Phenotype Annotation (1994-2006)

CITATIONS  (106)