FIGURE

Fig. 1

ID

ZDB-FIG-080604-68

Publication

Peri et al., 2008 - Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Microglia in the Zebrafish Brain

(A and B) Dorsal views of a 3 dpf (days post fertilization) embryonic wild-type brain. (A) Microglial expression of the Apo-E mRNA. (B) GFP expression under the control of the Apo-E locus.

(C) Schematic drawings of the regions of interest. Anterior is to the left. The upper panel represents a side view of a 3 dpf fish. The red bar marks the region and the depth at which confocal imaging has been performed. The lower part represents a dorsal view of the examined area (light red). The optic lobes are marked in dark red.

(D–F) Dorsal view of a 3 dpf wild-type embryonic brain. Double antibody (green [D]) and in situ (red [E]) staining show a perfect overlap between GFP and apo-E expression (F).

(G) Confocal time-lapse of one branching Apo-E wild-type microglial cell. Time is indicated in minutes.

Expression Data

Genes:	apoeb EGFP
Fish:	zf147Tg
Anatomical Term:	microglial cell
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Cell, 133(5), Peri, F., and Nüsslein-Volhard, C., Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo, 916-927, Copyright (2008) with permission from Elsevier. Full text @ Cell