FIGURE

Fig. 5

ID

ZDB-FIG-080516-36

Publication

Qu et al., 2008 - ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish

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Fig. 5

Attenuation of Ndrg4 results in early looping abnormalities. The cmlc2-driven GFP is expressed in cardiomyocytes of transgenic Tg(cmlc2:gfp) embryos. At 2 dpf (A?D) and 3 dpf (E?H), compared to the clearly looped heart of uninjected Tg(cmlc2:gfp) embryos (A, C, E, G), the heart of ndrg4 morphant (B, D, F, H) remained central and linear in a tubular structure. (A, B, E, F), Lateral views with anterior towards the left; (C, D, G, H), frontal views with anterior towards the top. a, atrium; v, ventricle.

Expression Data

Gene:	GFP
Fish:	f1Tg f1Tg + MO2-ndrg4
Knockdown Reagent:	MO2-ndrg4
Anatomical Terms:	atrium cardiac muscle cell cardiac ventricle
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	f1Tg + MO2-ndrg4
Knockdown Reagent:	MO2-ndrg4
Observed In:	blood circulation heart looping
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 317(2), Qu, X., Jia, H., Garrity, D.M., Tompkins, K., Batts, L., Appel, B., Zhong, T.P., and Baldwin, H.S., ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish, 486-496, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.