FIGURE

Fig. S2

ID

ZDB-FIG-080430-8

Publication

Jopling et al., 2007 - Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2-Induced Gastrulation Defects

Other Figures

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Fig. S2

Shp2 and Wnt5 Knockdown Acts Synergistically to Induce a Hammerhead Phenotype at 4 dpf
Shp2-MO and Wnt5-MO were injected at 50% of their normal concentration. By themselves, these injections did not induce defects (compare to morphology at 4 dpf with WT, noninjected control). Coinjection of Shp2-MO and Wnt5-MO did induce the hammerhead phenotype at 4 dpf. Note the blunted face and the increased distance between the eyes in the double-injected embryo (Shp2 + Wnt5).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-wnt5b WT + MO2-ptpn11a WT + MO1-wnt5b + MO2-ptpn11a
Knockdown Reagents:	MO1-wnt5b MO2-ptpn11a
Observed In:	cranial cartilage eye
Stage:	Day 4

Phenotype Detail

Acknowledgments

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