ZFIN ID: ZDB-FIG-080325-75
Bessa et al., 2008 - meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye. Development (Cambridge, England)   135(5):799-803 Full text @ Development
Knockdown Reagent:
Observed In:
Stage: Protruding-mouth

Fig. 2 meis1 is required for the growth of the eye primordium. (A,B) Lateral views of representative 72hpf control-MO (A) and meis1-MO (B) -injected fish. meis1 morphants are microphthalmic. (C,D) Confocal images of dissected eyes stained for propidium iodide (nuclei), rhodamine-phalloidin (filamentous actin) and Islet1, which labels GCL nuclei and some in the INL. The reduced eyes from meis1 morphants show apparently normal retina lamination (D,D′), but fewer cells than control eyes (C,C'). Area (E) and estimated volume (F) of control-MO and meis1-MO-injected embryos at 72hpf. meis1- morphant embryos show a significant (P<0.001) reduction in eye area and volume (45% and 60%, respectively). n=20 for each condition.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-meis1b standard conditions Protruding-mouth eye decreased size, abnormal
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development