ZFIN ID: ZDB-FIG-080325-74
Bessa et al., 2008 - meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye. Development (Cambridge, England)   135(5):799-803 Full text @ Development
Anatomical Terms:
Stage Range: 1-4 somites to High-pec

Fig. 1 meis1 retracts accompanying the ath5 wave and becomes restricted to the CMZ. (A-D) meis1 and (E-H) ath5 expression analyzed by single in situ hybridization. Developmental stages are indicated as hours post-fertilization (hpf) at 28.5°C. Lateral views of whole-mount (A,E) or dissected (B-D,F-H) eyes, with dorsal up and anterior to the left. The front of the ath5 domain is marked by black arrowheads. The red arrowhead in D points to meis1 expression in the prospective ciliary margin. (I-M) Transverse 40 μm vibratome sections. (I,J) Dorsal is up. meis1 is weakly expressed in the lens ectoderm before its thickening (I), but no signal is detected once the lens placode is formed (J). (K-M) Dorsal is to the left. meis1 and ath5 expression domains are complementary as shown by double in situ hybridization (K,L). Approximate limits of the ath5 signal are indicated by the black arrowheads. (M) At 42hpf, meis1 expression is detected by in situ hybridization in the ciliary margin (red arrowheads) and in the postmitotic ganglion cells (black arrowhead). L, lens.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
atoh7 WT standard conditions Prim-5 presumptive neural retina ISH
Prim-15 retina ISH
meis1b WT standard conditions 1-4 somites optic primordium ISH
14-19 somites optic vesicle ISH
Prim-5 optic cup ISH
Prim-5 presumptive neural retina ISH
Prim-15 retina ISH
High-pec retina ISH
High-pec retinal ganglion cell ISH
Antibody Labeling Details No data available
Phenotype Details No data available
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development