Fig. 3
- ID
- ZDB-FIG-071228-26
- Publication
- Holtzinger et al., 2007 - Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes
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The gata5 and gata6 genes are functionally redundant for atrial cardiomyocyte differentiation. Shown in each panel is a typical representative embryo following processing by whole mount in situ hybridization to detect transcripts for the atrial cardiomyocyte marker amhc at 32 hpf. Samples represent: wild-type embryos (WT), gata4 morphants (G4 MO), gata6 morphants (G6 MO), gata5 morphants (ssG5 MO or tbG5 MO), gata4+5 double morphants (G4+ssG5 MO or G4+tbG5 MO), gata4+6 double morphants (G4+6 MO), and gata5+6 double morphants (ssG5+6 MO and tbG5+6 MO). Despite morphogenetic defects, the atrium is specified in both gata4+6 and gata4+5 double morphants. However, ahmc transcripts are not detectable in gata5+6 double morphants. While these results were reproduced in multiple independent experiments, the number of embryos from the experiment represented in this figure by the phenotype (x) for a given number of embryos (n) is shown in each panel (x/n). Views are either ventral or dorsal, depending on the heart tube position, with anterior to the top. |
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| Stage: | Prim-15 |
Reprinted from Developmental Biology, 312(2), Holtzinger, A., and Evans, T., Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes, 613-622, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.