Gene

myh6

ID
ZDB-GENE-031112-1
Name
myosin, heavy chain 6, cardiac muscle, alpha
Symbol
myh6 Nomenclature History
Previous Names
  • myhc6 (1)
  • amhc (1)
  • atrial myosin heavy chain (1)
  • unm s459
  • unm_s459
  • wea
  • weak atrium
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in heart contraction and heart development. Predicted to localize to myosin complex. Is expressed in cardiac muscle; heart primordium; heart rudiment; and pericardial region. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
146 figures from 118 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
30 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myh6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
atrial heart septal defect 3 Alliance Atrial septal defect 3 614089
dilated cardiomyopathy 1EE Alliance Cardiomyopathy, dilated, 1EE 613252
hypertrophic cardiomyopathy 14 Alliance Cardiomyopathy, hypertrophic, 14 613251
{Sick sinus syndrome 3} 614090
Associated With myh6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin IQ motif-containing domain superfamily Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A4KUH9 244
UniProtKB:Q6YJK1 1936
UniProtKB:B3DJP9 1936
UniProtKB:B8JLS3 1936
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab-S46 monoclonal IgG1 , k Mouse
  • IHC
  • WB
Developmental Studies Hybridoma Bank
112
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations