FIGURE

Fig. 2

ID

ZDB-FIG-070911-31

Publication

Cheng et al., 2007 - Zebrafish homologue irx1a is required for the differentiation of serotonergic neurons

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Fig. 2

Expression of irx1a in hindbrain serotonergic neurons. A-H: Dorsal view of flat-mounted (A-D) and a lateral view (E-H) of a 48 hpf zebrafish brain region. A,B,E,F: irx1a is expressed in two rows of cells in rostral ventral hindbrain (black brackets, A,E) and have the same pattern as serotonergic neurons (B,F). C,D,G,H: The serotonergic markers Lmx1b1 (C,G) and Gata3 (D,H) are also expressed in the rostral ventral hindbrain. I-L: Transverse section of zebrafish hindbrain at rhombomere 1 position which are indicated in E-H, respectively. J: The serotonergic neurons are located in the ventral hindbrain (dashed lines) and irx1a is expressed in the same region. K: Lmx1b1 is expressed in the serotonergic neurons as well as in the floor plate. On the other hand, Gata3 is expressed in the serotonergic neurons but not the floorplate, and note that the ventral expression domain of Gata3 is boarder than the serotonergic neurons. M,P: Transverse section of zebrafish hindbrain at the otic vesicle region, which is indicated in E,F, respectively. The ventral expression domain of irx1a is on the boundary of notochord (dashed line circles in M) and is overlapped with serotonergic neurons (P). N,O: The other iro1 homologue irx1b (N) nor irx5a (O) are not expressed in this domain (N).

Expression Data

Genes:	gata3 irx1a irx1b irx5a lmx1bb
Fish:	WT
Anatomical Terms:	floor plate hindbrain otic vesicle serotonergic neuron
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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