Gene
irx1a
- ID
- ZDB-GENE-040707-1
- Name
- iroquois homeobox 1a
- Symbol
- irx1a Nomenclature History
- Previous Names
-
- ziro1a (1)
- zgc:109702
- zgc:136490
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including central nervous system neuron differentiation; embryonic morphogenesis; and eye development. Predicted to be active in nucleus. Is expressed in several structures, including liver; nervous system; neural plate; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human IRX1 (iroquois homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Iroquois-class homeodomain protein | KN homeodomain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JH33 | InterPro | 419 | |||||
| UniProtKB:Q90XQ7 | InterPro | 426 | |||||
| UniProtKB:A0A8M1PF69 | InterPro | 426 | |||||
| UniProtKB:A0A8M1PKM6 | InterPro | 419 |
Interactions and Pathways
No data available
Plasmids
No data available