ZFIN ID: ZDB-FIG-070911-10
Perner et al., 2007 - The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros. Developmental Biology   309(1):87-96 Full text @ Dev. Biol.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Prim-5 to Day 6

Fig. S2 Co-injection of wt1a and wt1b morpholinos induces an additive phenotype. Embryos injected either with control morpholino or with morpholinos targeting the first splice donor site of wt1a or wt1b, respectively, are shown. In the right panel embryos, which were co-injected with both wt1a and wt1b morpholinos are displayed. These embryos share features of wt1a morphants, like severe yolk sac edema (arrowhead), and wt1b morphants, like body curvature (asterisk).

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB/TU + MO1-wt1b standard conditions Prim-5 whole organism increased curvature, abnormal
Day 6 whole organism increased curvature, abnormal
AB/TU + MO1-wt1b + MO2-wt1a standard conditions Prim-5 whole organism increased curvature, abnormal
Day 6 whole organism increased curvature, abnormal
Day 6 yolk edematous, abnormal
AB/TU + MO2-wt1a standard conditions Prim-5 whole organism morphology, normal
Day 6 yolk edematous, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Developmental Biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Developmental Biology, 309(1), Perner, B., Englert, C., and Bollig, F., The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros, 87-96, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.