FIGURE

Fig. 5

ID

ZDB-FIG-070219-14

Publication

Hernandez et al., 2007 - Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development

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Fig. 5

Exogenous RA disrupts cyp26b1 and cyp26c1 expression in cyp26a1^-/- embryos but not in wild type. cyp26b1 (A-D) and cyp26c1 (E-H) expression (blue) is established normally in wild-type (A,E) and cyp26a1^-/- (B,F) embryos at the 6-somite stage (12 hpf). cyp26b1 and cyp26c1 expression is also established normally in wild-type embryos treated with a sub-teratogenic concentration of RA (5 nM; C,G), but not in cyp26a1^-/- embryos treated with 5 nM RA (D,H). krox20 expression is shown in red.

Expression Data

Genes:	cyp26b1 cyp26c1 egr2b
Fish:	cyp26a1^rw716/rw716
Condition:	chemical treatment: all-trans-retinoic acid
Anatomical Terms:	presumptive rhombomere 2 presumptive rhombomere 3 presumptive rhombomere 4 presumptive rhombomere 5 presumptive rhombomere 6
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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