Gene
cyp26b1
- ID
- ZDB-GENE-030131-2908
- Name
- cytochrome P450, family 26, subfamily b, polypeptide 1
- Symbol
- cyp26b1 Nomenclature History
- Previous Names
-
- dol
- fc21d03
- stocksteif (1)
- wu:fc21d03
- wu:fc26h10
- zgc:76999
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable retinoic acid 4-hydroxylase activity. Involved in negative regulation of retinoic acid receptor signaling pathway. Acts upstream of or within several processes, including retinoic acid catabolic process; skeletal system development; and tendon formation. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including brain; cranium; hindbrain neural keel; pectoral fin; and pleuroperitoneal region. Used to study craniosynostosis and osteochondrodysplasia. Orthologous to human CYP26B1 (cytochrome P450 family 26 subfamily B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 45 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1024 | Allele with one point mutation | Exon 6 | Nonsynonymous, Premature Stop | ENU | |
| la025910Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mz8 | unknown | Unknown | Unknown | CRISPR | |
| sa2 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa3 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| t24295 | unknown | Unknown | Unknown | not specified | |
| ti230g | unknown | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cyp26b1 | N/A | (4) |
| MO2-cyp26b1 | N/A | Hernandez et al., 2007 |
| MO3-cyp26b1 | N/A | Reijntjes et al., 2007 |
| MO4-cyp26b1 | N/A | White et al., 2007 |
| MO5-cyp26b1 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Craniosynostosis with radiohumeral fusions and other skeletal and craniofacial anomalies | 614416 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| osteochondrodysplasia | cyp26b1ti230g/ti230g | standard conditions | Laue et al., 2011 |
| craniosynostosis | cyp26b1t24295/t24295 | standard conditions | Laue et al., 2011 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group IV | Cytochrome P450 superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A0R4I9F4
|
511 | ||||
|
UniProtKB:Q6EIG3
|
511 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp26b1-201
(1)
|
Ensembl | 3,869 nt | ||
| ncRNA |
cyp26b1-002
(1)
|
Ensembl | 579 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(cyp26b1:Citrine) |
|
| 1 | (2) | |
| TgBAC(cyp26b1:YFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-51F7 | ZFIN Curated Data | |
| Contained in | BAC | CH73-368P22 | ZFIN Curated Data | |
| Contained in | BAC | CH211-197C14 | ||
| Encodes | EST | fc21d03 | ||
| Encodes | EST | fc26h10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76999 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212666 (1) | 3348 nt | ||
| Genomic | GenBank:AL935122 | 198363 nt | ||
| Polypeptide | UniProtKB:A0A0R4I9F4 (1) | 511 aa |
- Chen, B., Ran, Q., Chen, X., Deng, Z., Zhou, R., Zhang, Y., Liu, M., Li, B., Huang, S., Wang, P., Huang, S. (2024) Cxcr4a regulates heart progenitor development and cardiac rhythm in zebrafish. Biochemistry and biophysics reports. 39:101782101782
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Brandão, A.S., Borbinha, J., Pereira, T., Brito, P.H., Lourenço, R., Bensimon-Brito, A., Jacinto, A. (2022) A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration. eLIFE. 11
- Hu, B., Lelek, S., Spanjaard, B., El-Sammak, H., Simões, M.G., Mintcheva, J., Aliee, H., Schäfer, R., Meyer, A.M., Theis, F., Stainier, D.Y.R., Panáková, D., Junker, J.P. (2022) Origin and function of activated fibroblast states during zebrafish heart regeneration. Nature Genetics. 54(8):1227-1237
- Sehring, I.M., Mohammadi, H.F., Haffner-Luntzer, M., Ignatius, A., Huber-Lang, M., Weidinger, G. (2022) Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. eLIFE. 11:
- Sojan, J.M., Gioacchini, G., Giorgini, E., Orlando, P., Tiano, L., Maradonna, F., Carnevali, O. (2022) Zebrafish caudal fin as a model to investigate the role of probiotics in bone regeneration. Scientific Reports. 12:8057
- Sojan, J.M., Raman, R., Muller, M., Carnevali, O., Renn, J. (2022) Probiotics Enhance Bone Growth and Rescue BMP Inhibition: New Transgenic Zebrafish Lines to Study Bone Health. International Journal of Molecular Sciences. 23(9)
- Falfushynska, H., Horyn, O., Osypenko, I., Rzymski, P., Wejnerowski, Ł., Dziuba, M.K., Sokolova, I.M. (2021) Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio. Water research. 194:116923
- Hoffmann, S., Roeth, R., Diebold, S., Gogel, J., Hassel, D., Just, S., Rappold, G.A. (2021) Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other Genes. Frontiers in genetics. 12:688808
- Marqueño, A., Flores, C., Casado, M., Porte, C. (2021) Dysregulation of lipid metabolism in PLHC-1 and ZFL cells exposed to tributyltin an all-trans retinoic acid. Aquatic toxicology (Amsterdam, Netherlands). 231:105733
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