FIGURE

Fig. S2

ID

ZDB-FIG-070215-2

Publication

Zecchin et al., 2007 - Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish

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Fig. S2

Effects of knock down mediated by morpholinos directed against splicing of Notch ligands on the differentiation of pancreatic cell populations. Morpholinos are indicated on top of each group and probes on the left. glucagon expression in the pancreas is increased in jag1bspliMO-morphant embryos compared with mismatched controls (see also RT-PCR on Fig. S3). Moreover, expression of insulin in is increased while trypsin expression is decreased in jag2spliMO-morphants compared with mismatched controls. Embryos are in ventral view with anterior to the left. Stages are indicated at the bottom right of each frame.

Expression Data

Genes:	gcga ins prss1
Fish:	WT + MO3-jag1b WT + MO3-jag2b
Knockdown Reagents:	MO3-jag1b MO3-jag2b
Anatomical Term:	pancreas
Stage Range:	Long-pec to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 301(1), Zecchin, E., Filippi, A., Biemar, F., Tiso, N., Pauls, S., Ellertsdottir, E., Gnugge, L., Bortolussi, M., Driever, W., and Argenton, F., Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish, 192-204, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.