|ZFIN ID: ZDB-FIG-070214-5|
|Stage Range:||20-25 somites to Prim-15|
Fig. 8 Expression of insulin, somatostatin (PPSS2), glucagon, pax6.2 and pdx1 in ins:Gal4;UAS:NICD bi-genic embryos. Mono-genic control embryos (ins:Gal4 neg and UAS:NICD pos) are on the left and bi-genic embryos (ins:Gal4 pos and UAS:NICD pos) are on the right. Expression of NICD under the control of the insulin promoter leads to the lack of insulin-producing cells but somatostatin and glucagon producing cells are present similarly to control. Genes whose expression is analyzed are indicated on the left while the genotypes are indicated on the top. Embryos are in ventral views with anterior to the left. Individual embryos were genotyped by PCR for presence or absence of each transgene. Scale bar is 50 μm.
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Reprinted from Developmental Biology, 301(1), Zecchin, E., Filippi, A., Biemar, F., Tiso, N., Pauls, S., Ellertsdottir, E., Gnugge, L., Bortolussi, M., Driever, W., and Argenton, F., Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish, 192-204, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.