ZFIN CRISPR: CRISPR2-hoxc13a

Target Location

Genome Build: GRCz11Chromosome: 23

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115	hoxc1a, hoxc3a, hoxc4a, hoxc5a, hoxc6a, hoxc8a, hoxc9a, hoxc10a, hoxc11a, hoxc12a, hoxc13a
sud124d	hoxc13b
sud133b	hoxc13a
sud135	hoxc13a

Expression

Gene expression in Wild Types + CRISPR2-hoxc13a

No data available

Phenotype

Phenotype resulting from CRISPR2-hoxc13a

No data available

Phenotype of all Fish created by or utilizing CRISPR2-hoxc13a

Phenotype	Fish	Conditions	Figures
vertebra 16 transformed to vertebra 15, abnormal	Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115 (RW)	standard conditions	Fig. 4 from Yamada et al., 2021
tripus transformed to parapophysis 2, abnormal	Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115 (RW)	standard conditions	Fig. 4 from Yamada et al., 2021
vertebra 15 transformed to vertebra 14, abnormal	Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115 (RW)	standard conditions	Fig. 4 from Yamada et al., 2021
swim bladder morphology, abnormal	Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115 (RW)	standard conditions	Fig. 6 from Yamada et al., 2021
somite increased amount, abnormal	Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115 (RW)	standard conditions	Fig. 5 from Yamada et al., 2021
os suspensorium absent, abnormal	Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115 (RW)	standard conditions	Fig. 4 from Yamada et al., 2021
whole organism semi-viable, abnormal	Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115 (RW)	standard conditions	Table 1 from Yamada et al., 2021
vertebra increased amount, abnormal	Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115 (RW)	standard conditions	Fig. 5 from Yamada et al., 2021
somite border increased amount, abnormal	Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115 (RW)	standard conditions	Fig. 5 from Yamada et al., 2021
vertebra increased amount, abnormal	hoxc13a^{sud133b/sud133b}; hoxc13b^{sud134b/sud134b}	standard conditions	Fig. 2 from Adachi et al., 2024
tripus anterior region decreased length, abnormal	hoxc11b^{sud124b/sud124b}; hoxc12b^{sud124c/sud124c}; hoxc13b^{sud124d/sud124d}; hoxc6b^{sud124a/sud124a} (RW)	standard conditions	Fig. 4 from Yamada et al., 2021
anal fin lepidotrichium increased amount, exacerbated	hoxc12a^{sud133a/sud133a}; hoxc12b^{sud134a/sud134a}; hoxc13a^{sud133b/sud133b}; hoxc13b^{sud134b/sud134b}	standard conditions	Fig. 2 from Adachi et al., 2024
vertebra increased amount, abnormal	hoxc12a^{sud133a/sud133a}; hoxc12b^{sud134a/sud134a}; hoxc13a^{sud133b/sud133b}; hoxc13b^{sud134b/sud134b}	standard conditions	Fig. 2 from Adachi et al., 2024
ventral fin fold posterior orientation, abnormal	hoxc12a^{sud133a/sud133a}; hoxc12b^{sud134a/sud134a}; hoxc13a^{sud133b/sud133b}; hoxc13b^{sud134b/sud134b}	standard conditions	Fig. 2 from Adachi et al., 2024
anal fin radial increased amount, exacerbated	hoxc12a^{sud133a/sud133a}; hoxc12b^{sud134a/sud134a}; hoxc13a^{sud133b/sud133b}; hoxc13b^{sud134b/sud134b}	standard conditions	Fig. 2 from Adachi et al., 2024
vertebra increased amount, abnormal	hoxc12a^{sud133a/sud133a}; hoxc11a^{sud141/sud141}; hoxc11b^{sud128/sud128}; hoxc12b^{sud134a/sud134a}; hoxc13a^{sud133b/sud133b}; hoxc13b^{sud134b/sud134b}	standard conditions	Fig. 3 from Adachi et al., 2024
dorsal fin lepidotrichium increased amount, exacerbated	hoxc12a^{sud133a/sud133a}; hoxc11a^{sud141/sud141}; hoxc11b^{sud128/sud128}; hoxc12b^{sud134a/sud134a}; hoxc13a^{sud133b/sud133b}; hoxc13b^{sud134b/sud134b}	standard conditions	Fig. 3 from Adachi et al., 2024
anal fin radial increased amount, abnormal	hoxc6b^sud124a/+; Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115	standard conditions	Fig. 1 from Adachi et al., 2024
abdominal musculature posterior region increased amount, abnormal	hoxc6b^sud124a/+; Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115	standard conditions	Fig. 1 from Adachi et al., 2024
whole organism posterior region increased height, abnormal	hoxc6b^sud124a/+; Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115	standard conditions	Fig. 1 from Adachi et al., 2024
anal fin lepidotrichium increased amount, abnormal	hoxc6b^sud124a/+; Df(Chr23:hoxc13a,hoxc12a,hoxc11a,hoxc10a,hoxc9a,hoxc8a,hoxc6a,hoxc5a,hoxc4a,hoxc3a,hoxc1a)sud115/sud115	standard conditions	Fig. 1 from Adachi et al., 2024

Citations

Include unpublished citations

Adachi, U., Koita, R., Seto, A., Maeno, A., Ishizu, A., Oikawa, S., Tani, T., Ishizaka, M., Yamada, K., Satoh, K., Nakazawa, H., Furudate, H., Kawakami, K., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Teleost Hox code defines regional identities competent for the formation of dorsal and anal fins. Proceedings of the National Academy of Sciences of the United States of America. 121:e2403809121e2403809121
Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):

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