ZFIN ID: ZDB-GENE-991119-8

Gene Name:MAD homolog 1 (Drosophila)
Gene Symbol: smad1

Previous Names: fb39h09, madh1, SMA- and MAD-related protein 1, wu:fb97e04, wu:fb39h09(1)
Nomenclature History

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GENE EXPRESSION:(current status)

All expression data:	12 figure(s) from 4 publications
Directly submitted expression data:	6 figure(s) (19 images) from Thisse et al., 2004 [MGC:92101]
Wild Type Stages, Structures:	Zygote:1-cell (0.00h-0.75h) to Adult (90d-730d, breeding adult)
	adaxial cell, axial chorda mesoderm ... (all 24)
Curated microarray expression:	GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   3 genotypes
Allele(s):   fh243, fh245, unrec_smad1

Phenotype: (current status)

Data:	2 figures from McReynolds et al., 2007
Observed in:	brain, endoderm, extension, heart, heart looping ... (all 10)

Knockdown reagents: MO1-smad1 (1) ,   MO2-smad1 (1)

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GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Biological Process	BMP signaling pathway (more)
Cellular Component	cytoplasm (more)
Molecular Function	sequence-specific DNA binding transcription factor activity (more)

All GO Terms (13)

Protein Families, Domains and Sites:

InterPro:IPR001132 (1) InterPro:IPR003619 (1) InterPro:IPR008984 (1) InterPro:IPR013019 (1) InterPro:IPR013790 (1) InterPro:IPR017855 (1)

PROSITE:PS51075 (1) PROSITE:PS51076 (1)

Pfam:PF03165 (1) Pfam:PF03166 (1)

Gene Product Description

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ANTIBODIES:

Ab1-smad (5)

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SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

smad1 Contained in	[BAC] CH211-194G2 (1)    (order this)
smad1 Encodes	[EST] fb39h09 , fb97e04 (1) [cDNA] MGC:92101 (1)    (order this)

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131356 (1)	1419 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX276105 (1)	209486 bp	- Select Tool - MegaBLAST
Polypeptide	UniProtKB:Q7T082 (1)	473 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:76928 (1)
All Sequence Information (18)

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OTHER  smad1  GENE / MARKER PAGES:

Entrez Gene:30628 (1)

VEGA:OTTDARG00000019473 (1)

Ensembl(Zv8):ENSDARG00000027199 (1)

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MAPPING INFORMATION:

LG:  1    Details

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ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	smad1	1
Human	SMAD1	4 (q31)	OMIM:601595 Entrez Gene:4086
Mouse	Smad1	8 (syntenic)	MGI:109452 Entrez Gene:17125
Orthology Details

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CITATIONS   (28)