ZFIN ID: ZDB-GENE-031014-1
Gene Name: SMAD family member 9
Gene Symbol: smad9    Nomenclature History

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Previous Names: madh9, smad8, zgc:103407 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in dorsal/ventral pattern formation; myeloid cell development; and negative regulation of transcription, DNA-templated. Predicted to localize to the cytoplasm; nucleus; and transcription factor complex. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Is expressed in several structures, including cardiovascular system; gut; nervous system; optic vesicle; and periderm. Orthologous to human SMAD9 (SMAD family member 9).
Genome Resources: Alliance (1),  Gene:445564 (1), 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011859Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • um112 Small Deletion Unknown Frameshift ZINC_FINGER_NUCLEASE
    um113 Small Deletion Unknown Frameshift ZINC_FINGER_NUCLEASE
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-smad9 N/A 2
    MO2-smad9 N/A 2
    DISEASE ASSOCIATED WITH smad9 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary pulmonary hypertension Alliance Pulmonary hypertension, primary, 2 615342
    DISEASE ASSOCIATED WITH smad9 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    arteriovenous malformations of the brain zf531Tg + MO1-smad9 standard conditions Walcott et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001132 SMAD domain, Dwarfin-type
    Domain IPR001173 Glycosyltransferase 2-like
    Domain IPR003619 MAD homology 1, Dwarfin-type
    Domain IPR013019 MAD homology, MH1
    Domain IPR035518 Dolichyl-phosphate beta-glucosyltransferase
    Family IPR013790 Dwarfin
    Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
    Homologous_superfamily IPR017855 SMAD-like domain superfamily
    Homologous_superfamily IPR029044 Nucleotide-diphospho-sugar transferases
    Homologous_superfamily IPR036578 SMAD MH1 domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smad9-001 (1)    Ensembl 2359
    ncRNA smad9-002 (1)    Ensembl 917
    smad9-003 (1)    Ensembl 526
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-smad polyclonal IgG Rabbit IHC, WB Cell Signaling Technology, Inc.
    67
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smad9 No data available
    MARKER RELATIONSHIPS
    smad9 Contained in: [BAC] CH211-170H2 (1)
    smad9 Encodes: [cDNA] MGC:103407 (1), MGC:192433 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004014 (1) 1978 nt
    Genomic GenBank:CT573139 (1) 159802 nt
    Select Tool
    Polypeptide UniProtKB:B2GS20 (1) 466 aa
    Sequence Information (all 21)
    ORTHOLOGY for smad9 ( Chr: 10 )
    CITATIONS (32)