Gene

smad9

ID
ZDB-GENE-031014-1
Name
SMAD family member 9
Symbol
smad9 Nomenclature History
Previous Names
  • madh9
  • smad8
  • zgc:103407 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have DNA binding activity and DNA-binding transcription factor activity. Involved in dorsal/ventral pattern formation; myeloid cell development; and negative regulation of transcription, DNA-templated. Predicted to localize to several cellular components, including integral component of membrane; nucleus; and transcription factor complex. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Is expressed in several structures, including cardiovascular system; gut; nervous system; optic vesicle; and periderm. Orthologous to human SMAD9 (SMAD family member 9).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smad9 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary pulmonary hypertension Alliance Pulmonary hypertension, primary, 2 615342
Associated With smad9 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001132 SMAD domain, Dwarfin-type
Domain IPR003619 MAD homology 1, Dwarfin-type
Domain IPR013019 MAD homology, MH1
Family IPR013790 Dwarfin
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Homologous_superfamily IPR036578 SMAD MH1 domain superfamily
Domain Details Per Protein
Protein Length Dwarfin MAD homology 1, Dwarfin-type MAD homology, MH1 SMAD domain, Dwarfin-type SMAD/FHA domain superfamily SMAD-like domain superfamily SMAD MH1 domain superfamily
UniProtKB:B2GS20 466
UniProtKB:Q6A3P7 466
UniProtKB:F1QXZ9 466
UniProtKB:Q5XJE0 466
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-smad polyclonal IgG Rabbit
  • IHC
  • WB
Cell Signaling Technology, Inc.
75
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations