ZFIN ID: ZDB-GENE-991119-8
Gene Name: SMAD family member 1
Gene Symbol: smad1
Sequence Ontology ID : SO:0000704

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Previous Names: madh1, fb39h09, sb:eu786, SMA- and MAD-related protein 1, wu:fb39h09 (1), wu:fb97e04

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(Including Attributions)
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits protein heterodimerization activity; involved in several processes, including dorsal/ventral pattern formation, embryonic pattern specification, and regulation of cellular biosynthetic  ...
GENE EXPRESSION
All Expression Data: 31 figures from 15 publications
Directly Submitted Expression Data: 6 figures (19 images) from Thisse et al., 2004 [MGC:92101]
  6 figures (20 images) from Thisse et al., 2005 [eu786]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh243 Point Mutation Unknown Unknown ENU
fh245 Point Mutation Intron 2 - Exon 3 Splice Junction Unknown
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la013641Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32712 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32713 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • smad1_unrecovered Point Mutation Unknown Unknown ENU
    zko668a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • zko668b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 9 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH smad1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH smad1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein heterodimerization activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001132 (1)
  • InterPro:IPR003619 (1)
  • InterPro:IPR008984 (1)
  • InterPro:IPR013019 (1)
  • InterPro:IPR013790 (1)
  • InterPro:IPR017855 (1)
  • InterPro:IPR036578 (1)
  • PROSITE:PS51075 (1)
  • PROSITE:PS51076 (1)
  • Pfam:PF03165 (1)
  • Pfam:PF03166 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA smad1-201 (1) 3022
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM smad1 No data available
    MARKER RELATIONSHIPS
    smad1Contained in: [BAC] CH211-194G2 (1) (order this)
    smad1Encodes: [EST] eu786 (1), fb39h09, fb97e04 (1)
    [cDNA] MGC:92101 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131356 (1) 1419bp
    Genomic GenBank:BX276105 (1) 209486bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q7T082 (1) 473aa
    Sequence Clusters UniGene:76928 (1)
    Sequence Information (all 27)
    OTHER smad1 GENE PAGES
  • Alliance (1)
  • Gene:30628 (1)
  • VEGA:OTTDARG00000019473 (1)
  • ORTHOLOGY for smad1 (Chr: 1)
    CITATIONS (71)