ZFIN ID: ZDB-GENE-990603-9
Gene Name: SMAD family member 5
Gene Symbol: smad5    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: madh5, smd5 (1), fb67b04, pgy (1), piggytail (1), sb:cb400, sbn, SMA- and MAD-related protein 5, somitabun, wu:fb67b04 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits transcription regulatory region DNA binding activity. Involved in several processes, including embryonic morphogenesis; regulation of transcription, DNA-templated; and vasculature development. Predicted to localize to cytoplasm; nucleus; and transcription factor complex. Is expressed in eye and posterior lateral line primordium. Orthologous to human SMAD5 (SMAD family member 5).
Genome Resources: Alliance (1),  Gene:30641 (1),  Ensembl(GRCz11):ENSDARG00000037238 (2)
GENE EXPRESSION
All Expression Data: 18 figures from 16 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55211]
  1 figure (1 image) from Thisse et al., 2005 [eu319]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1100 Point Mutation Unknown Missense
dfr3 Point Mutation Unknown Missense ENU
dtc24 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • dti216c Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • dty40 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • fr4 Point Mutation Unknown Missense ENU
    fr5 Point Mutation Unknown Premature Stop ENU
    la027522Tg Transgenic Insertion Unknown Unknown DNA
    m169 Point Mutation Unknown Cryptic Acceptor Splice Site, Frameshift, Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14393 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • smad5_unspecified Unspecified Unknown Unknown
    st30 Point Mutation Unknown Missense ENU
    st31 Point Mutation Unknown Missense ENU
    st32 Point Mutation Unknown Missense ENU
    ta206 Unknown Unknown Unknown ENU
    tc227a Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tx223 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-smad5 N/A 7
    MO2-smad5 N/A 1
    MO3-smad5 N/A 5
    MO4-smad5 N/A 4
    MO5-smad5 N/A 3
    MO6-smad5 N/A 1
    TALEN1-smad5
    1
    DISEASE ASSOCIATED WITH smad5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH smad5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of ventral identity (more)
    Cellular Component cytoplasm (more)
    Molecular Function transcription regulatory region sequence-specific DNA binding (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smad5-201 (1)    Ensembl 2551
    smad5-202 (1)    Ensembl 894
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-smad polyclonal IgG Rabbit IHC, WB Cell Signaling Technology, Inc.
    69
    Ab1-smad5 polyclonal IgG Rabbit GeneTex
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smad5 No data available
    MARKER RELATIONSHIPS
    smad5 Contained in: [BAC] DKEYP-110E4 (1)
    smad5 Contains: [SNP] rs3728635 (1), rs3728636 (1), rs3728637 (1), rs3728638 (1), rs3728639 (1), rs3728640 (1), rs3728641 (1)
    smad5 Encodes: [EST] eu319 (1), fb67b04 (1)
    [cDNA] MGC:55211 (1), MGC:76817 (1), MGC:174444 (1), MGC:174796 (1), MGC:192783 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131368 (1) 2572 nt
    Genomic GenBank:BX323077 (1) 195732 nt
    Select Tool
    Polypeptide UniProtKB:A5PMC0 (1) 464 aa
    Sequence Information (all 47)
    ORTHOLOGY for smad5 ( Chr: 14 )
    CITATIONS (129)