ZFIN ID: ZDB-GENE-990415-8

Gene Name:paired box gene 2a
Gene Symbol: pax2a

Previous Names: Pax-2, noi, pax2.1, pax[zf-b], paxb, Pax2.1, cb378(1) , pax-b, pax2a1, no isthmus
Nomenclature History

---

GENE EXPRESSION:(current status)

All expression data:	417 figure(s) from 291 publications
Directly submitted expression data:	6 figure(s) (47 images) from Thisse et al., 2001 [cb378]
Wild Type Stages, Structures:	Cleavage:8-cell (1.25h-1.50h) to Larval:Protruding-mouth (72.00h-96.00h, 3.5mm)
	brain, central nervous system ... (all 79)
Curated microarray expression:	GEO  (1)

---

MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   19 genotypes
Allele(s):   b593, rk9, tb21, th44, tm243a ... (all 9)

Phenotype: (current status)

Data:	29 figures from 17 publications
Observed in:	anatomical system, blood circulation, brain, brush border, caudal commissure ... (all 40)

Knockdown reagents: MO1-pax2a (1) ,   MO2-pax2a (1) ,   MO3-pax2a (1)

---

GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Biological Process	anterior/posterior pattern formation (more)
Cellular Component	nucleus
Molecular Function	DNA binding

All GO Terms (21)

Protein Families, Domains and Sites:

InterPro:IPR001523 (1) InterPro:IPR009057 (1) InterPro:IPR011991 (1) InterPro:IPR022130 (1)

PROSITE:PS00034 (1) PROSITE:PS51057 (1)

Pfam:PF00292 (1) Pfam:PF12403 (1)

Gene Product Description

---

CONSTRUCTS WITH SEQUENCE FROM pax2a:

Tg(pax2a:lacZ), Tg(pax2a:GFP)

---

SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

pax2a Contained in	[BAC] CH73-104D2 (1)    (order this) , DKEY-254E7 (1)    (order this)
pax2a Encodes	[EST] cb378 (1) [cDNA] MGC:76865 (1)    (order this)

---

SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131184 (1)	2959 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CT025909 (1)	204435 bp	- Select Tool - MegaBLAST
Polypeptide	UniProtKB:Q90268 (1)	410 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:75076 (1)
All Sequence Information (40)

---

OTHER  pax2a  GENE / MARKER PAGES:

Entrez Gene:30425 (1)

VEGA:OTTDARG00000027765 (1)

Ensembl(Zv8):ENSDARG00000028148 (1)

---

MAPPING INFORMATION:

LG:  13  Details

View Map: Merged  Individual Panels

---

ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	pax2a	13
Human	PAX2	10 (q24)	OMIM:167409 Entrez Gene:5076
Mouse	Pax2	19 (43.00 cM)	MGI:97486 Entrez Gene:18504
Orthology Details

---

CITATIONS   (497)