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General Information
ZIRC
ZFIN ID: ZDB-FISH-150901-25192
Fish name: pax2atu29a/tu29a
Genotype: pax2atu29a/tu29a
Targeting Reagent: none
Current Source: Nüsslein-Volhard Lab (alive)
HUMAN DISEASE MODELED by pax2atu29a/tu29a
Human Disease Conditions Citations
coloboma standard conditions Moosajee et al., 2008
GENE EXPRESSION
Gene expression in pax2atu29a/tu29a
RNA expression
Expressed Gene Structure Conditions Figures
bcl2l1 control Fig. 4 with image from Porreca et al., 2012
cdh1 standard conditions Fig. 5 with image from Kantarci et al., 2016
cldna standard conditions Fig. 2 with image from Hans et al., 2004
cntn2 standard conditions text only from Scholpp et al., 2003
ctsba standard conditions Fig. 1 with image from Alt et al., 2006
cyb5a standard conditions Fig. 7 with image from Lupo et al., 2011
dact1 standard conditions Fig. 7 with image from Lupo et al., 2011
dhrs3a standard conditions Fig. 7 with image from Lupo et al., 2011
dusp6 standard conditions text only from Tsang et al., 2004
ek1 standard conditions text only from Scholpp et al., 2003
en1a standard conditions Fig. 8 with image from Lun et al., 1998
en2a standard conditions text only from Scholpp et al., 2003
Fig. 6 with imageFig. 8 with image from Lun et al., 1998
en2b standard conditions text only from Tallafuss et al., 2003
Fig. 6 with imageFig. 8 with image from Lun et al., 1998
Fig. 7 with image from Pfeffer et al., 1998
epha4a standard conditions text only from Teraoka et al., 2004
text only from Scholpp et al., 2003
text only from Scholpp et al., 2003
epha4b standard conditions text only from Scholpp et al., 2003
fgf8a standard conditions Fig. 9 with image from Heisenberg et al., 1999
Fig. 6 with image from Lun et al., 1998
Fig. 9 with image from Reifers et al., 1998
fgfr3 standard conditions text only from Tallafuss et al., 2003
gsc standard conditions Fig. 4 with image from Kantarci et al., 2016
her5 standard conditions text only from Tallafuss et al., 2003
Fig. 6 with imageFig. 8 with image from Lun et al., 1998
her11 standard conditions Fig. 3 with image from Ninkovic et al., 2005
isl1 standard conditions text only from Scholpp et al., 2003
itga5 standard conditions Fig. 7 with image from Lupo et al., 2011
neurog1 standard conditions Fig. 4 with image from Kantarci et al., 2016
nkx2.2a standard conditions text only from Scholpp et al., 2003
nkx2.4b standard conditions Fig. 1 with image from Alt et al., 2006
nos2b control Fig. 2 with image from Poon et al., 2008
ntn1a standard conditions Fig. 7 with image from Lupo et al., 2011
otx2b standard conditions text only from Tallafuss et al., 2003
pax2a standard conditions Fig. 5 with image from Shima et al., 2009
Fig. 3 with image from Ninkovic et al., 2005
Fig. 6 with image from Lun et al., 1998
pax2b standard conditions Fig. 7 with image from Pfeffer et al., 1998
pax5 standard conditions Fig. 7 with image from Kwak et al., 2006
text only from Scholpp et al., 2003
Fig. 8 with image from Pfeffer et al., 1998
pax6a standard conditions text only from Scholpp et al., 2003
text only from Scholpp et al., 2003
text only from Tallafuss et al., 2003
text only from Tallafuss et al., 2003
pax8 standard conditions Fig. 9 with image from Pfeffer et al., 1998
pdzrn3b standard conditions Fig. 3 with image from Dente et al., 2011
phox2a standard conditions Fig. 6 from Guo et al., 1999
ponzr1 standard conditions Fig. 3 with image from Bedell et al., 2012
rdh10a standard conditions Fig. 7 with image from Lupo et al., 2011
ret standard conditions Fig. 6 with image from Majumdar et al., 2000
shha standard conditions text only from Scholpp et al., 2003
six3a standard conditions text only from Tallafuss et al., 2003
th standard conditions Fig. 6 from Guo et al., 1999
tp73 standard conditions Fig. 4 with image from Rentzsch et al., 2003
tph2 standard conditions text only from Teraoka et al., 2004
vax1 standard conditions Fig. 7 with image from Lupo et al., 2011
wnt1 standard conditions text only from Scholpp et al., 2003
text only from Tallafuss et al., 2003
Fig. 6 with image from Lun et al., 1998
wnt4 standard conditions text only from Scholpp et al., 2003
wt1a standard conditions Fig. 5 with image from Shima et al., 2009
znf503 standard conditions Fig. 7 with image from Lupo et al., 2011
Protein expression
Antibody Antigen Genes Structure Conditions Figures
Ab1-pax2 standard conditions Fig. 3 with image from Batista et al., 2008
zn-5 standard conditions Fig. 5 with image from Shima et al., 2009
Reporter gene expression No data available
PHENOTYPE
Phenotype in pax2atu29a/tu29a
Phenotype Conditions Figures
anatomical system quality, abnormal standard conditions Fig. for (tu29a) from Phenotype Annotation (1994-2006)
apoptotic process increased occurrence, abnormal standard conditions Fig. 7 with image from Kwak et al., 2006
blood circulation disrupted, abnormal standard conditions text only from Brand et al., 1996
brain lacks all parts of type midbrain hindbrain boundary, abnormal standard conditions Fig. 4 with image from Porreca et al., 2012
Fig. 7 with image from Pfeffer et al., 1998
brain quality, abnormal standard conditions Fig. for (tu29a) from Phenotype Annotation (1994-2006)
caudal commissure increased size, abnormal standard conditions Fig. 2 with image from Scholpp et al., 2003
cerebellum absent, abnormal standard conditions Fig. 1 with image from Lun et al., 1998
text only from Brand et al., 1996
commissura cerebelli aplastic, abnormal standard conditions Fig. 1 with image from Scholpp et al., 2003
cranial ganglion neuron decreased amount, abnormal standard conditions Fig. S1 with image from Nechiporuk et al., 2007
cranial nerve II malformed, abnormal standard conditions Fig. 4 from Macdonald et al., 1997
cranial nerve IV aplastic, abnormal standard conditions Fig. 1 with image from Scholpp et al., 2003
diencephalon distended, abnormal standard conditions text only from Scholpp et al., 2003
epiphysis decreased width, abnormal standard conditions Fig. 2 with image from Scholpp et al., 2003
eye decreased size, abnormal standard conditions Fig. 7 from Moosajee et al., 2008
gut epithelium edematous, abnormal standard conditions Fig. 1 with image from Lun et al., 1998
heart edematous, abnormal standard conditions Fig. 5 with image from Shima et al., 2009
hindbrain distended, abnormal standard conditions text only from Scholpp et al., 2003
lens decreased size, abnormal standard conditions Fig. 7 from Moosajee et al., 2008
lens opaque, abnormal standard conditions Fig. 7 from Moosajee et al., 2008
locus ceruleus development disrupted, abnormal standard conditions Fig. 6 from Guo et al., 1999
locus coeruleus absent, abnormal standard conditions Fig. 6 from Guo et al., 1999
midbrain hindbrain boundary absent, abnormal standard conditions Fig. 1 with image from Lun et al., 1998
text only from Brand et al., 1996
Table 2 from Chen et al., 1996
midbrain hindbrain boundary aplastic, abnormal standard conditions Fig. 1 with image from Scholpp et al., 2003
midbrain hindbrain boundary physical object quality, abnormal standard conditions Fig. 9 with image from Pfeffer et al., 1998
Fig. 9 with image from Reifers et al., 1998
midbrain hindbrain boundary physical object quality, normal standard conditions Fig. 9 with image from Reifers et al., 1998
midbrain hindbrain boundary quality, abnormal standard conditions Fig. for (tu29a) from Phenotype Annotation (1994-2006)
midbrain hindbrain boundary neural keel physical object quality, abnormal standard conditions Fig. 8 with image from Pfeffer et al., 1998
midbrain-hindbrain boundary development arrested, abnormal standard conditions Fig. 1 with image from Lun et al., 1998
midbrain-hindbrain boundary development decreased process quality, abnormal standard conditions Fig. 9 with image from Reifers et al., 1998
midbrain-hindbrain boundary development process quality, normal standard conditions Fig. 9 with image from Reifers et al., 1998
midbrain-hindbrain boundary initiation process quality, abnormal standard conditions Fig. 7 with image from Pfeffer et al., 1998
nervous system quality, abnormal standard conditions Fig. for (tu29a) from Phenotype Annotation (1994-2006)
optic chiasm cranial nerve II ipsilateral to optic chiasm cranial nerve II, abnormal standard conditions Fig. 5 with image from Shima et al., 2009
optic cup physical object quality, abnormal standard conditions Fig. 9 with image from Pfeffer et al., 1998
optic nerve development disrupted, abnormal standard conditions Fig. 4 from Macdonald et al., 1997
optic tectum absent, abnormal standard conditions Fig. 1 with image from Lun et al., 1998
text only from Brand et al., 1996
optic tectum aplastic, abnormal standard conditions Fig. 1 with image from Scholpp et al., 2003
optic tectum apoptotic, abnormal standard conditions Fig. 2 with image from Brand et al., 1996
optic tectum decreased size, abnormal standard conditions Table 1 from Trowe et al., 1996
optic tectum morphology, abnormal standard conditions Table 1 from Trowe et al., 1996
otic vesicle decreased size, abnormal standard conditions Fig. 5 with image from Shima et al., 2009
text only from Brand et al., 1996
otic vesicle morphology, normal standard conditions Fig. 5 with image from Mackereth et al., 2005
otic vesicle physical object quality, abnormal standard conditions Fig. 8 with image from Pfeffer et al., 1998
otic vesicle neuroblast delamination increased occurrence, abnormal standard conditions Fig. 4 with image from Kantarci et al., 2016
otic vesicle neuroblast proliferation decreased occurrence, abnormal standard conditions Fig. 4 with image from Kantarci et al., 2016
otic vesicle ventro-lateral region gsc expression increased distribution, abnormal standard conditions Fig. 4 with image from Kantarci et al., 2016
parasympathetic nervous system development disrupted, abnormal standard conditions Fig. S1 with image from Nechiporuk et al., 2007
pericardium edematous, abnormal standard conditions Fig. 7 from Moosajee et al., 2008
Fig. 1 with image from Lun et al., 1998
pronephric duct absent, abnormal standard conditions text only from Brand et al., 1996
pronephric duct lacks all parts of type epithelial cell brush border, abnormal standard conditions Fig. 6 with image from Majumdar et al., 2000
pronephric duct physical object quality, abnormal standard conditions Fig. 9 with image from Pfeffer et al., 1998
pronephric duct central region distended, abnormal standard conditions Fig. 6 with image from Majumdar et al., 2000
pronephric duct epithelial cell flattened, abnormal standard conditions Fig. 6 with image from Majumdar et al., 2000
pronephros absent, abnormal standard conditions Table 2 from Chen et al., 1996
pronephros physical object quality, abnormal standard conditions Fig. 9 with image from Pfeffer et al., 1998
pronephros quality, abnormal standard conditions Fig. for (tu29a) from Phenotype Annotation (1994-2006)
pronephros development process quality, abnormal standard conditions Fig. 1 with image from Majumdar et al., 2000
retina layer formation disrupted, abnormal standard conditions Fig. 7 from Moosajee et al., 2008
retinal ganglion cell axon guidance process quality, abnormal standard conditions Table 1 from Trowe et al., 1996
retinal ganglion cell axon guidance quality, abnormal standard conditions Fig. for (tu29a) from Phenotype Annotation (1994-2006)
retinal neural layer closure incomplete, abnormal standard conditions Fig. 3 from Macdonald et al., 1997
retinal pigmented epithelium closure incomplete, abnormal standard conditions Fig. 3 from Macdonald et al., 1997
swim bladder aplastic, abnormal standard conditions Fig. 7 from Moosajee et al., 2008
thyroid follicle aplastic, abnormal standard conditions Fig. 4 from Wendl et al., 2002
utricle lacks parts or has fewer parts of type hair cell, abnormal standard conditions Fig. 7 with image from Kwak et al., 2006
whole organism decreased length, abnormal standard conditions Fig. 7 from Moosajee et al., 2008
whole organism lethal (sensu genetics), abnormal standard conditions Fig. for (tu29a) from Phenotype Annotation (1994-2006)
whole organism viability, abnormal standard conditions Table 1 from Trowe et al., 1996

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