ZFIN ID: ZDB-GENE-990415-8
Gene Name: paired box 2a
Gene Symbol: pax2a

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Previous Names: Pax-2, pax-b, pax2.1, Pax2.1, pax2a1, paxb, cb378 (1), no isthmus, noi, pax[zf-b]

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 691 figures from 478 publications
Directly Submitted Expression Data: 6 figures (47 images) from Thisse et al., 2001 [cb378]
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Adult (90d-730d, breeding adult)
  anterior neural keel, anterior neural rod, blastoderm, brain (all 156) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b593 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • pax2a_unspecified Unspecified Unknown Unknown
    rk9 Unknown Unknown Unknown
    sa11077 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22324 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24936 Point Mutation Unknown Premature Stop ENU
    tb21 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • th44 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm243a Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tu29a Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty22b Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty31a Point Mutation Unknown Unknown ENU
    Targeting reagents: MO1-pax2a (1), MO2-pax2a (1), MO3-pax2a (1), MO4-pax2a (1), MO5-pax2a (1) (all 6) expand
    PHENOTYPE
    Data: 47 figures from 27 publications
    Observed in: anatomical system, ansulate commissure, apoptotic process, blood circulation (all 68) expand
    DISEASE ASSOCIATED WITH pax2a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    focal segmental glomerulosclerosis Glomerulosclerosis, focal segmental, 7 616002
    renal coloboma syndrome Papillorenal syndrome 120330
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001523 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR011991 (1)
  • InterPro:IPR022130 (1)
  • PROSITE:PS00034 (1)
  • PROSITE:PS51057 (1)
  • Pfam:PF00292 (1)
  • Pfam:PF12403 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pax2a-001 (1) 3050
    pax2a-002 (1) 1202
    pax2a-003 (1) 1171
    pax2a-004 (1) 1190
    pax2a-005 (1) 1221
    ncRNA pax2a-006 (1) 323
    mRNA pax2a-007 (1) 1145
    pax2a-008 (1) 1126
    pax2a-009 (1) 879
    pax2a-010 (1) 1148
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-pax2 (1), Ab1-pax2a (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM pax2a
    Tg(hsp70l:pax2a), Tg(pax2a:Cre-ERT2), Tg(pax2a:GFP), Tg(pax2a:Kaede), Tg(pax2a:lacZ)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pax2aContained in: [BAC] CH73-104D2 (1) (order this), DKEY-254E7 (1) (order this)
    pax2aEncodes: [EST] cb378 (1)
    [cDNA] MGC:76865 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131184 (1) 2959bp
    Genomic GenBank:CT025909 (1) 204435bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IJW2 (1) 476aa
    Sequence Clusters UniGene:75076 (1)
    Sequence Information (all 83)
    OTHER pax2a GENE PAGES
  • Gene:30425 (1)
  • VEGA:OTTDARG00000027765 (1)
  • Ensembl(GRCz10):ENSDARG00000028148 (1)
  • ORTHOLOGY for pax2a (Chr: 13)
    CITATIONS (810)