ZFIN ID: ZDB-GENE-990415-8
Gene Name: paired box 2a
Gene Symbol: pax2a
Sequence Ontology ID : SO:0000704

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Previous Names: Pax-2, pax-b, pax2.1, Pax2.1, pax2a1, paxb, cb378 (1), no isthmus, noi, pax[zf-b]

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 692 figures from 479 publications
Directly Submitted Expression Data: 6 figures (47 images) from Thisse et al., 2001 [cb378]
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Adult (90d-730d, breeding adult)
  anterior neural keel, anterior neural rod, blastoderm, brain (all 156) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b593 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • pax2a_unspecified Unspecified Unknown Unknown
    rk9 Unknown Unknown Unknown
    sa11077 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22324 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24936 Point Mutation Unknown Premature Stop ENU
    tb21 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • th44 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm243a Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tu29a Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty22b Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty31a Point Mutation Unknown Unknown ENU
    Targeting reagents: MO1-pax2a (1), MO2-pax2a (1), MO3-pax2a (1), MO4-pax2a (1), MO5-pax2a (1) (all 6) expand
    PHENOTYPE
    Data: 47 figures from 27 publications
    Observed in: anatomical system, ansulate commissure, apoptotic process, blood circulation (all 68) expand
    DISEASE ASSOCIATED WITH pax2a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    focal segmental glomerulosclerosis 7 Glomerulosclerosis, focal segmental, 7 616002
    renal coloboma syndrome Papillorenal syndrome 120330
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001523 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR011991 (1)
  • InterPro:IPR022130 (1)
  • PROSITE:PS00034 (1)
  • PROSITE:PS51057 (1)
  • Pfam:PF00292 (1)
  • Pfam:PF12403 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pax2a-001 (1) 3050
    pax2a-002 (1) 1202
    pax2a-003 (1) 1171
    pax2a-004 (1) 1190
    pax2a-005 (1) 1221
    ncRNA pax2a-006 (1) 323
    mRNA pax2a-007 (1) 1145
    pax2a-008 (1) 1126
    pax2a-009 (1) 879
    pax2a-010 (1) 1148
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-pax2 (1), Ab1-pax2a (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM pax2a
    Tg(hsp70l:pax2a), Tg(pax2a:Cre-ERT2), Tg(pax2a:GFP), Tg(pax2a:Kaede), Tg(pax2a:lacZ)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pax2aContained in: [BAC] CH73-104D2 (1) (order this), DKEY-254E7 (1) (order this)
    pax2aEncodes: [EST] cb378 (1)
    [cDNA] MGC:76865 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131184 (1) 2959bp
    Genomic GenBank:CT025909 (1) 204435bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IJW2 (1) 476aa
    Sequence Clusters UniGene:75076 (1)
    Sequence Information (all 83)
    OTHER pax2a GENE PAGES
  • Gene:30425 (1)
  • VEGA:OTTDARG00000027765 (1)
  • Ensembl(GRCz10):ENSDARG00000028148 (1)
  • ORTHOLOGY for pax2a (Chr: 13)
    CITATIONS (818)