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ZIRC
ZFIN ID: ZDB-GENE-990415-8
Gene Name: paired box 2a
Gene Symbol: pax2a
Sequence Ontology ID : SO:0000704

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Previous Names: Pax-2, pax-b, pax2.1, Pax2.1, pax2a1, paxb, cb378 (1), no isthmus, noi, pax[zf-b]

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits sequence-specific DNA binding activity. Involved in several processes, including animal organ development; cilium assembly; and peripheral nervous system development. Localizes to the  ...
GENE EXPRESSION
All Expression Data: 728 figures from 506 publications
Directly Submitted Expression Data: 6 figures (47 images) from Thisse et al., 2001 [cb378]
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b593 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • pax2a_unspecified Unspecified Unknown Unknown
    rk9 Unknown Unknown Unknown
    sa11077 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22324 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24936 Point Mutation Unknown Premature Stop ENU
    tb21 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • th44 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm243a Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tu29a Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty22b Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty31a Point Mutation Unknown Missense ENU
    umn100 Small Deletion Exon 2 Unknown TALEN
    umn101 Insertion Exon 2 Unknown TALEN
    uy221Tg Transgenic Insertion 5' UTR Unknown DNA_AND_CRISPR
    Targeting reagents:
    PHENOTYPE
    Data: 53 figures from 32 publications
    Observed in:
    DISEASE ASSOCIATED WITH pax2a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    focal segmental glomerulosclerosis 7 Glomerulosclerosis, focal segmental, 7 616002
    renal coloboma syndrome Papillorenal syndrome 120330
    DISEASE ASSOCIATED WITH pax2a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    coloboma pax2atu29a/tu29a standard conditions Moosajee et al., 2008
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 28)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA pax2a-006 (1) 323
    mRNA pax2a-202 (1) 3050
    pax2a-203 (1) 1148
    pax2a-205 (1) 1126
    pax2a-206 (1) 1221
    pax2a-207 (1) 879
    pax2a-208 (1) 1202
    pax2a-209 (1) 1190
    pax2a-210 (1) 1171
    pax2a-211 (1) 1145
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS
    Addgene
    MARKER RELATIONSHIPS
    pax2aContained in: [BAC] CH73-104D2 (1) (order this), DKEY-254E7 (1) (order this)
    pax2aEncodes: [EST] cb378 (1)
    [cDNA] MGC:76865 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131184 (1) 2959bp
    Genomic GenBank:CT025909 (1) 204435bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IAI2 (1) 417aa
    Sequence Clusters UniGene:75076 (1)
    Sequence Information (all 111)
    ORTHOLOGY for pax2a (Chr: 13)
    CITATIONS (881)