Gene

kdm1a

ID
ZDB-GENE-030131-7828
Name
lysine (K)-specific demethylase 1a
Symbol
kdm1a Nomenclature History
Previous Names
  • kdm1
  • aof2
  • lsd1 (1)
  • wu:fb82e06
  • wu:fc51a02
  • wu:fj36a05
  • wu:fj66b06
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have several functions, including chromatin binding activity; flavin adenine dinucleotide binding activity; and histone demethylase activity (H3-dimethyl-K4 specific). Involved in nervous system development; regulation of hemopoiesis; and regulation of retinoic acid biosynthetic process. Predicted to localize to nuclear chromatin. Is expressed in brain; head; intestine; and spinal cord. Orthologous to human KDM1A (lysine demethylase 1A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
aik5Allele with one deletionExon 1Missense, Premature StopCRISPR
it627Allele with one point mutationExon 17Premature StopENU
sa23095Allele with one point mutationUnknownSplice SiteENU
sa28869Allele with one point mutationUnknownUnknownENU
sa36433Allele with one point mutationUnknownPremature StopENU
sa42949Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Human Disease
Associated With kdm1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cleft palate, psychomotor retardation, and distinctive facial features 616728
{ACTH-independent macronodular adrenal hyperplasia 3} 620990
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Associated With kdm1a Via Experimental Models
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Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002937 Amine oxidase
Domain IPR007526 SWIRM domain
Family IPR017366 Lysine-specific histone demethylase
Family IPR050281 Flavin monoamine oxidase and related enzymes
Homologous_superfamily IPR009057 Homedomain-like superfamily
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Domain Details Per Protein
Protein Length Amine oxidase FAD/NAD(P)-binding domain superfamily Flavin monoamine oxidase and related enzymes Homedomain-like superfamily Lysine-specific histone demethylase SWIRM domain Winged helix-like DNA-binding domain superfamily
UniProtKB:F6NIA2 833
UniProtKB:A0A0P0UQI8 830
UniProtKB:A0JMQ3 848
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA kdm1a-201 (1) Ensembl 3,367 nt
mRNA kdm1a-202 (1) Ensembl 887 nt
mRNA kdm1a-203 (1) Ensembl 500 nt
mRNA kdm1a-204 (1) Ensembl 456 nt
mRNA kdm1a-207 (1) Ensembl 606 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-265G24ZFIN Curated Data
EncodesESTfb82e06
EncodesESTfc51a02
EncodesESTfj36a05
EncodesESTfj66b06
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanKDM1A1
Conserved genome location (synteny) (1)
Functional complementation (1)
Nucleotide sequence comparison (1)
Amino acid sequence comparison (2)
MouseKdm1a4
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations