Gene
kdm1a
- ID
- ZDB-GENE-030131-7828
- Name
- lysine (K)-specific demethylase 1a
- Symbol
- kdm1a Nomenclature History
- Previous Names
-
- kdm1
- aof2
- lsd1 (1)
- wu:fb82e06
- wu:fc51a02
- wu:fj36a05
- wu:fj66b06
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have several functions, including chromatin binding activity; flavin adenine dinucleotide binding activity; and histone demethylase activity (H3-dimethyl-K4 specific). Involved in nervous system development; regulation of hemopoiesis; and regulation of retinoic acid biosynthetic process. Predicted to localize to nuclear chromatin. Is expressed in brain; head; intestine; and spinal cord. Orthologous to human KDM1A (lysine demethylase 1A).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
aik5 | Allele with one deletion | Exon 1 | Missense, Premature Stop | CRISPR | |
it627 | Allele with one point mutation | Exon 17 | Premature Stop | ENU | |
sa23095 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa28869 | Allele with one point mutation | Unknown | Unknown | ENU | |
sa36433 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa42949 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Show
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
myelodysplastic syndrome | AB + MO4-kdm1a | standard conditions | Wu et al., 2021 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Amine oxidase | FAD/NAD(P)-binding domain superfamily | Flavin monoamine oxidase and related enzymes | Homedomain-like superfamily | Lysine-specific histone demethylase | SWIRM domain | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:F6NIA2
|
833 | |||||||
UniProtKB:A0A0P0UQI8
|
830 | |||||||
UniProtKB:A0JMQ3
|
848 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001242995 (1) | 3352 nt | ||
Genomic | GenBank:AL844186 (1) | 221158 nt | ||
Polypeptide | UniProtKB:A0JMQ3 (1) | 848 aa |