Gene
cdh1
- ID
- ZDB-GENE-010606-1
- Name
- cadherin 1, type 1, E-cadherin (epithelial)
- Symbol
- cdh1 Nomenclature History
- Previous Names
-
- E-cadherin (1)
- hab
- half baked
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables G-protein alpha-subunit binding activity. Involved in convergent extension involved in gastrulation and embryonic cleavage. Acts upstream of or within several processes, including adherens junction maintenance; embryonic morphogenesis; and germ cell migration. Located in several cellular components, including adherens junction; cell cortex; and microvillus. Part of catenin complex. Is expressed in several structures, including axial mesoderm; blastoderm; germ ring; nervous system; and pronephros. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1) and CDH3 (cadherin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 67 figures from 48 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu736 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| dtv43 | Allele with one point mutation | Unknown | Missense | ENU | |
| la011658Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| rk3 | Allele with one point mutation | Intron 1 | Splice Site, Premature Stop | ENU | |
| sa41032 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| tm94 | Allele with one point mutation | Unknown | Missense | ENU | |
| ts18 | Allele with one point mutation | Unknown | Missense | ENU | |
| tx230 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| vu44 | Allele with one point mutation | Unknown | Premature Stop | not specified | |
| xt17Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| xt18Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdh1 | (10) | |
| CRISPR2-cdh1 | Tsai et al., 2020 | |
| CRISPR3-cdh1 | Tsai et al., 2020 | |
| CRISPR4-cdh1 | Tsai et al., 2020 | |
| CRISPR5-cdh1 | Tsai et al., 2020 | |
| CRISPR6-cdh1 | Campbell et al., 2021 | |
| CRISPR7-cdh1 | Campbell et al., 2021 | |
| MO1-cdh1 | N/A | Kane et al., 2005 |
| MO2-cdh1 | N/A | (4) |
| MO3-cdh1 | N/A | (27) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| blepharocheilodontic syndrome 1 | Alliance | Blepharocheilodontic syndrome 1 | 119580 |
| breast cancer | Alliance | Breast cancer, lobular, somatic | 114480 |
| endometrial cancer | Alliance | Endometrial carcinoma, somatic | 608089 |
| hereditary diffuse gastric cancer | Alliance | Diffuse gastric and lobular breast cancer syndrome with or without cleft lip and/or palate | 137215 |
| ovarian cancer | Alliance | Ovarian cancer, somatic | 167000 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cadherin | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Cadherin prodomain | Cadherin, Y-type LIR-motif | Catenin binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90Z37
|
864 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pan-Cadherin | polyclonal | Rabbit |
|
Sigma-Aldrich
|
29 | ||
| AB1-cdh1 | polyclonal | Rabbit |
|
12 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(cdh1:cdh1-sfGFP,cryaa:Cerulean) |
|
| 1 | (4) | |
| TgBAC(cdh1:cdh1-TagRFP,cryaa:Cerulean) |
|
| 1 | (2) | |
| Tg(UAS:cdh1,cryaa:Cerulean) |
|
| 1 | (2) | |
| Tg(UAS:cdh1-GFP) |
|
| 1 | Haraoka et al., 2022 | |
| Tg(ubb:LOXP-EGFP-LOXP-cdh1-2A-Tomato) |
| 1 | Cronan et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-289B2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-173L11 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-125P9 | ZFIN Curated Data | |
| Encodes | EST | eu736 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131820 (1) | 3340 nt | ||
| Genomic | GenBank:BX322631 (2) | 161710 nt | ||
| Polypeptide | UniProtKB:Q90Z37 (1) | 864 aa |
- Camacho-Macorra, C., Tabanera, N., Sánchez-Bustamante, E., Bovolenta, P., Cardozo, M.J. (2024) Maternal vgll4a regulates zebrafish epiboly through Yap1 activity. Frontiers in cell and developmental biology. 12:13626951362695
- Hu, B., Pinzour, J., Patel, A., Rooney, F., Zerwic, A., Gao, Y., Nguyen, N.T., Xie, H., Ye, D., Lin, F. (2024) Gα13 controls pharyngeal endoderm convergence by regulating E-cadherin expression and RhoA activation. Development (Cambridge, England). 151(19):
- Luo, G., Zeng, D., Liu, J., Li, D., Takiff, H.E., Song, S., Gao, Q., Yan, B. (2023) Temporal and cellular analysis of granuloma development in mycobacterial infected adult zebrafish. Journal of Leukocyte Biology. 115(3):525-535
- Mignani, L., Facchinello, N., Varinelli, M., Massardi, E., Tiso, N., Ravelli, C., Mitola, S., Schu, P., Monti, E., Finazzi, D., Borsani, G., Zizioli, D. (2023) Deficiency of AP1 Complex Ap1g1 in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies. International Journal of Molecular Sciences. 24(8):
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- Boutillon, A., Escot, S., Elouin, A., Jahn, D., González-Tirado, S., Starruß, J., Brusch, L., David, N.B. (2022) Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception. Developmental Cell. 57(12):1529-1544.e5
- Haraoka, Y., Akieda, Y., Nagai, Y., Mogi, C., Ishitani, T. (2022) Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis. Nature communications. 13:1417
- Liu, M., Zou, X., Fu, M., Bai, X., Zhao, Y., Chen, X., Wang, X., Wang, P., Huang, S. (2022) Mild cold stress specifically disturbs clustering movement of DFCs and sequential organ left-right patterning in zebrafish. Frontiers in cell and developmental biology. 10:952844
- Lu, J.W., Lin, L.I., Sun, Y., Liu, D., Gong, Z. (2022) Effect of Lipopolysaccharides on Liver Tumor Metastasis of twist1a/krasV12 Double Transgenic Zebrafish. Biomedicines. 10(1):
- Mu, X., Qi, S., Wang, H., Yuan, L., Wang, C., Li, Y., Qiu, J. (2022) Bisphenol analogues induced metabolic effects through eliciting intestinal cell heterogeneous response. Environment International. 165:107287
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