ZFIN ID: ZDB-GENE-010606-1
Gene Name: cadherin 1, type 1, E-cadherin (epithelial)
Gene Symbol: cdh1
Previous Names: E-cadherin (1), hab, half baked
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 45 figures from 31 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2005 [eu736]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  anatomical structure, anterior axial hypoblast, anterior neural rod, axial chorda mesoderm (all 43) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dtv43 Point Mutation Unknown Unknown ENU
la011658Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rk3 Point Mutation Unknown Unknown ENU
    sa41032 Point Mutation Unknown Unknown ENU
    tm94 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ts18 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tx230 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vu44 Point Mutation Unknown Unknown
    Targeting reagents: MO1-cdh1 (1), MO2-cdh1 (1), MO3-cdh1 (1), MO4-cdh1 (1), MO5-cdh1 (1) (all 6) expand
    PHENOTYPE
    Data: 18 figures from 9 publications
    Observed in: axial hypoblast filopodium, cell migration involved in gastrulation, cell-cell adhesion involved in gastrulation, cell-cell adhesion involved in mesendodermal cell migration (all 27) expand
    DISEASE ASSOCIATED WITH cdh1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    breast cancer {Breast cancer, lobular} 114480
    endometrial carcinoma Endometrial carcinoma, somatic 608089
    ovarian cancer Ovarian carcinoma, somatic 167000
    prostate cancer {Prostate cancer, susceptibility to} 176807
    stomach cancer Gastric cancer, familial diffuse, with or without cleft lip and/or palate 137215
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process epiboly involved in gastrulation with mouth forming second (more)
    Cellular Component catenin complex (more)
    Molecular Function G-protein alpha-subunit binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000233 (1)
  • InterPro:IPR002126 (1)
  • InterPro:IPR014868 (1)
  • InterPro:IPR015919 (1)
  • InterPro:IPR020894 (1)
  • InterPro:IPR027397 (1)
  • PROSITE:PS00232 (1)
  • PROSITE:PS50268 (1)
  • Pfam:PF00028 (1)
  • Pfam:PF01049 (1)
  • Pfam:PF08758 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cdh1-001 (1) 2494
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    AB1-cdh1 (1), Ab1-pan-Cadherin (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM cdh1
    Tg(UAS:cdh1,cryaa:Cerulean)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cdh1Contained in: [BAC] CH73-289B2 (1) (order this), DKEY-173L11 (1) (order this)
    [Fosmid] CH1073-125P9 (1) (order this)
    cdh1Encodes: [EST] eu736 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131820 (1) 3340bp
    Genomic GenBank:BX322631 (1) 161710bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IL00 (1) 877aa
    Sequence Clusters UniGene:78411 (1)
    Sequence Information (all 20)
    OTHER cdh1 GENE PAGES
  • Gene:114424 (1)
  • VEGA:OTTDARG00000020300 (1)
  • Ensembl(GRCz10):ENSDARG00000102750 (1)
  • ORTHOLOGY for cdh1 (Chr: 7)
    Species Symbol Chromosome Accession # Evidence
    Human CDH1 16
  • Gene:999
  • OMIM:192090
  • HGNC:1748
  • Amino acid sequence comparison (2)
    Nucleotide sequence comparison (1)
    Mouse Cdh1 8
  • MGI:88354
  • Gene:12550
  • Amino acid sequence comparison (2)
    Nucleotide sequence comparison (1)
    Download Curated Orthology
    CITATIONS (95)