Gene

cdh1

ID
ZDB-GENE-010606-1
Name
cadherin 1, type 1, E-cadherin (epithelial)
Symbol
cdh1 Nomenclature History
Previous Names
  • E-cadherin (1)
  • hab
  • half baked
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits G-protein alpha-subunit binding activity. Involved in several processes, including adherens junction maintenance; embryonic morphogenesis; and germ cell migration. Localizes to several cellular components, including adherens junction; catenin complex; and microvillus. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple). Is expressed in several structures, including axial mesoderm; blastoderm; germ ring; nervous system; and pronephros. Orthologous to human CDH1 (cadherin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
58 figures from 41 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdh1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
blepharocheilodontic syndrome 1 Alliance Blepharocheilodontic syndrome 1 119580
breast cancer Alliance Breast cancer, lobular, somatic 114480
endometrial cancer Alliance Endometrial carcinoma, somatic 608089
hereditary diffuse gastric cancer Alliance Diffuse gastric and lobular breast cancer syndrome with or without cleft lip and/or palate 137215
ovarian cancer Alliance Ovarian cancer, somatic 167000
prostate cancer Alliance {Prostate cancer, susceptibility to} 176807
Associated With cdh1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020894 Cadherin conserved site
Domain IPR000233 Cadherin, cytoplasmic domain
Domain IPR002126 Cadherin-like
Domain IPR014868 Cadherin prodomain
Family IPR030049 Cadherin-1
Family IPR039808 Cadherin
Homologous_superfamily IPR015919 Cadherin-like superfamily
Homologous_superfamily IPR027397 Catenin binding domain superfamily
Domain Details Per Protein
Protein Length Cadherin Cadherin-1 Cadherin conserved site Cadherin, cytoplasmic domain Cadherin-like Cadherin-like superfamily Cadherin prodomain Catenin binding domain superfamily
UniProtKB:A0A0R4IFF8 877
UniProtKB:A0A0R4IJR6 864
UniProtKB:Q90Z37 864
UniProtKB:A0A0R4IQ86 796
UniProtKB:A0A0R4IL00 877
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pan-Cadherin polyclonal Rabbit
  • IHC
  • WB
Sigma-Aldrich
27
AB1-cdh1 polyclonal Rabbit
  • IHC
  • WB
11
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations