Gene

cdh1

ID
ZDB-GENE-010606-1
Name
cadherin 1, type 1, E-cadherin (epithelial)
Symbol
cdh1 Nomenclature History
Previous Names
  • E-cadherin (1)
  • hab
  • half baked
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits G-protein alpha-subunit binding activity. Involved in several processes, including adherens junction maintenance; embryonic morphogenesis; and germ cell migration. Localizes to several cellular components, including adherens junction; catenin complex; and microvillus. Is expressed in several structures, including axial mesoderm; blastoderm; germ ring; nervous system; and pronephros. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1).
Genome Resources
Note
None
Expression
All Expression Data
57 figures from 40 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdh1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
blepharocheilodontic syndrome 1 Alliance Blepharocheilodontic syndrome 1 119580
breast cancer Alliance {Breast cancer, lobular} 114480
endometrial cancer Alliance Endometrial carcinoma, somatic 608089
hereditary diffuse gastric cancer Alliance Gastric cancer, hereditary diffuse, with or without cleft lip and/or palate 137215
ovarian cancer Alliance Ovarian cancer, somatic 167000
prostate cancer Alliance {Prostate cancer, susceptibility to} 176807
Associated With cdh1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020894 Cadherin conserved site
Domain IPR000233 Cadherin, cytoplasmic domain
Domain IPR002126 Cadherin-like
Domain IPR014868 Cadherin prodomain
Family IPR039808 Cadherin
Homologous_superfamily IPR015919 Cadherin-like superfamily
Homologous_superfamily IPR027397 Catenin binding domain superfamily
Domain Details Per Protein
Protein Length Cadherin Cadherin conserved site Cadherin, cytoplasmic domain Cadherin-like Cadherin-like superfamily Cadherin prodomain Catenin binding domain superfamily
UniProtKB:Q90Z37 864
UniProtKB:A0A0R4IJR6 864
UniProtKB:A0A0R4IQ86 796
UniProtKB:A0A0R4IL00 877
UniProtKB:A0A0R4IFF8 877
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pan-Cadherin polyclonal Rabbit
  • IHC
  • WB
Sigma-Aldrich
26
AB1-cdh1 polyclonal Rabbit
  • IHC
  • WB
11
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations