PUBLICATION
Zebrafish E-cadherin: Expression during early embryogenesis and regulation during brain development
- Authors
- Babb, S.G., Barnett, J., Doedens, A.L., Cobb, N., Liu, Q., Sorkin, B.C., Yelick, P.C., Raymond, P.A., and Marrs, J.A.
- ID
- ZDB-PUB-010601-7
- Date
- 2001
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 221(2): 231-237 (Journal)
- Registered Authors
- Clendenon, Sherry, Liu, Qin, Marrs, James A., Raymond, Pamela, Yelick, Pamela C.
- Keywords
- cadherin; zebrafish; Danio rerio; neurogenesis; midbrain; hindbrain; wnt1; pax2.1; cyclops
- MeSH Terms
-
- Sequence Analysis, DNA
- Reverse Transcriptase Polymerase Chain Reaction
- Time Factors
- Signal Transduction
- Cadherins/biosynthesis*
- Brain/embryology*
- Nervous System/embryology
- Nicotinamide-Nucleotide Adenylyltransferase
- PAX2 Transcription Factor
- Nucleotidyltransferases/genetics
- Nucleotidyltransferases/metabolism*
- DNA-Binding Proteins/biosynthesis
- Animals
- Transcription Factors/biosynthesis
- Zebrafish
- Embryo, Nonmammalian/metabolism*
- Fungal Proteins/biosynthesis
- Gene Expression Regulation*
- Gene Library
- Zebrafish Proteins
- DNA, Complementary/metabolism
- Blotting, Northern
- Tissue Distribution
- In Situ Hybridization
- PubMed
- 11376490 Full text @ Dev. Dyn.
Citation
Babb, S.G., Barnett, J., Doedens, A.L., Cobb, N., Liu, Q., Sorkin, B.C., Yelick, P.C., Raymond, P.A., and Marrs, J.A. (2001) Zebrafish E-cadherin: Expression during early embryogenesis and regulation during brain development. Developmental Dynamics : an official publication of the American Association of Anatomists. 221(2):231-237.
Abstract
Zebrafish E-cadherin (cdh1) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis. Expression was observed in blastomeres, the anterior mesoderm during gastrulation, and developing epithelial structures. In the developing nervous system, cdh1 was detected at the pharyngula stage (24 hpf) in the midbrain-hindbrain boundary (MHB). Developmental regulation of MHB formation involves wnt1 and pax2.1. wnt1 expression preceded cdh1 expression during MHB formation, and cdh1 expression in the MHB was dependent on normal development of this structure.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping