ZFIN ID: ZDB-LAB-100915-1
YH Chen Lab
PI/Director: Chen, Yau-Hung
Contact Person: Chen, Yau-Hung
Email: yauhung@mail.tku.edu.tw
URL: http://www2.tku.edu.tw/~tscx/2009chinese/teachers/teacher_view.php?id=22
Address: Molecular and Developmental Biology Laboratory Department of Chemistry Tamkang University 151 Ying-chuan Road Tamsui, Taipei County 25137 Taiwan
Country: Taiwan
Phone: +886-2-26215656 ext 3009
Fax: +886-2-26209924
Line Designation: tku

Show all 2 genomic features

1. Molecular mechanisms of muscle and craniofacial development
2. Skin carcinogenesis and basal cell carcinoma
3. Anti-cancer metallodrug screening
4. Food and drug toxicology

Liao, Yun-Feng Post-Doc Ding, Yu-Ju Graduate Student Pai, Chiung-Wen Graduate Student

Huang, H.T., Huang, C.Y., Lee, C.J., Sun, B.J., Jhang, Z.W., Wen, C.C., Wang, Y.H., Li, T.S., Chern, C.Y., Chen, Y.H. (2024) The angiogenesis-modulating effects of coumarin-derivatives. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 278:109862
Pan, H.C., Chen, Y.H., Fang, W.C., Wu, V.C., Sun, C.Y. (2022) Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury. International Journal of Molecular Sciences. 23(16)
Liu, C.F., Ou-Yang, Y., Huang, C.Y., Jao, S.W., Kuo, Y.K., Chen, H.C., Cheng, S.C., Wang, N.K., Chuang, L.H., Chen, Y.H., Chen, W.Y. (2022) Zebrafish (Danio rerio) Is an Economical and Efficient Animal Model for Screening Potential Anti-cataract Compounds. Translational vision science & technology. 11:21
Tang, P.W., Wu, P.H., Lin, Y.T., Chiu, C.H., Cheng, T.L., Guan, W.H., Lin, H.Y., Lee, K.T., Chen, Y.H., Chiu, C.C., Liu, W. (2022) Zebrafish Model-Based Assessment of Indoxyl Sulfate-Induced Oxidative Stress and Its Impact on Renal and Cardiac Development. Antioxidants (Basel, Switzerland). 11(2):
Lai, C.Y., Yeh, K.Y., Liu, B.F., Chang, T.M., Chang, C.H., Liao, Y.F., Liu, Y.W., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish. Cancers. 13(21):
Lu, P.H., Lee, H.Y., Liou, Y.L., Tung, S.F., Kuo, K.L., Chen, Y.H. (2020) Nephroprotective Role of Zhibai Dihuang Wan in Aristolochic Acid-Intoxicated Zebrafish. BioMed Research International. 2020:5204348
Tsai, J.N., Sun, C.Y., Ding, Y.J., Wang, Y.H., Lo, K.C., Wen, C.C., Lin, J.W., Chang, C.F., Hsu, L.S., Chen, H.M., Fong, T.H., Chen, Y.H. (2018) Embryonic exposure to 4-methylimidazole leads to zebrafish myofibril misalignment. Environmental toxicology. 33(12):1321-1328
Sun, C.Y., Wu, M.S., Lee, C.C., Chen, S.H., Lo, K.C., Chen, Y.H. (2018) A novel SNP in the 5' regulatory region of organic anion transporter 1 is associated with chronic kidney disease. Scientific Reports. 8:8085
Lai, Y.H., Ding, Y.J., Moses, D., Chen, Y.H. (2017) Teratogenic Effects of Topiramate in a Zebrafish Model. International Journal of Molecular Sciences. 18(8):1721
Yan, D., Ni, L.K., Chen, H.L., Chen, L.C., Chen, Y.H., Cheng, C.C. (2016) Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo. Bioorganic & medicinal chemistry letters. 26(3):774-7
Chen, Y.H., Chang, C.F., Lai, Y.Y., Sun, C.Y., Ding, Y.J., Tsai, J.N. (2015) von Hippel-Lindau gene plays a role during zebrafish pronephros development. In vitro cellular & developmental biology. Animal. 51(10):1023-32
Chen, Y.H., Chou, C.Y., Sun, C.Y. (2015) Impairment of the cellular distribution and stability of the erythropoietin receptor through the direct targeting of aristolochic acid. Toxicological sciences : an official journal of the Society of Toxicology. 147(1):246-54
Ding, Y.J., Wang, B.C., Wen, C.C., Sun, C.Y., Lee, H.H., Lee, F.P., Yang, L.L., Chen, Y.H. (2015) Evaluation of the teratogenic effects of three traditional Chinese medicines, Si Jun Zi Tang, Liu Jun Zi Tang and Shenling Baizhu San, during zebrafish pronephros development. Journal of Toxicologic Pathology. 28:141-149
Wu, H.J., Fong, T.H., Chen, S.L., Wei, J.C., Wang, I.J., Wen, C.C., Chang, C.Y., Chen, X.G., Chen, W.Y., Chen, H.M., Horng, J.L., Wang, Y.H., Chen, Y.H. (2015) Perturbation of cytosolic calcium by 2-aminoethoxydiphenyl borate and caffeine affects zebrafish myofibril alignment. Journal of applied toxicology : JAT. 35(3):287-94
Ding, Y.J., Sun, C.Y., Wen, C.C., Chen, Y.H. (2015) Nephroprotective Role of Resveratrol and Ursolic Acid in Aristolochic Acid Intoxicated Zebrafish. toxins. 7:97-109
Chang, W.N., Lee, G.H., Kao, T.T., Lin, C.Y., Hsiao, T.H., Tsai, J.N., Chen, B.H., Chen, Y.H., Wu, H.R., Tsai, H.J., Fu, T.F. (2014) Knocking down 10-formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement. Biochimica et biophysica acta. General subjects. 1840(7):2340-2350
Cheng, C.C., Chou, C.Y., Chang, Y.C., Wang, H.W., Wen, C.C., Chen, Y.H. (2014) Protective Role of Comfrey Leave Extracts on UV-induced Zebrafish Fin Damage. Journal of Toxicologic Pathology. 27:115-21
Chen, Y.H., Lee, Y.T., Wen, C.C., Chen, Y.C., Chen, Y.J. (2014) Modeling pegylated liposomal doxorubicin-induced hand-foot syndrome and intestinal mucositis in zebrafish. OncoTargets and therapy. 7:1169-75
Chen, X.G., Wang, Y.H., Wen, C.C., Chen, Y.H. (2014) Overdose of D-serine Induces Movement Disorder and Neuromuscular Changes of Zebrafish Larvae. Journal of Toxicologic Pathology. 27:19-24
Han, H.W., Chou, C.M., Chu, C.Y., Cheng, C.H., Yang, C.H., Hung, C.C., Hwang, P.P., Lee, S.J., Liao, Y.F., and Huang, C.J. (2014) The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor. PLoS One. 9(1):e86345
Chen, Y.H., Pai, C.W., Huang, S.W., Chang, S.N., Lin, L.Y., Chiang, F.T., Lin, J.L., Hwang, J.J., and Tsai, C.T. (2013) Inactivation of Myosin binding protein C homolog in zebrafish as a model for human cardiac hypertrophy and diastolic dysfunction. Journal of the American Heart Association. 2(5):e000231
Lin, M.D., Lee, H.T., Wang, S.C., Li, H.R., Hsien, H.L., Cheng, K.W., Chang, Y.D., Huang, M.L., Yu, J.K., and Chen, Y.H. (2013) Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish. BMC Developmental Biology. 13:18
Tsai, I.T., Chen, Y.H., Chen, Y.H., and Wang, Y.H. (2013) Amikacin-induced Fin Reduction is Mediated by Autophagy. Journal of Toxicologic Pathology. 26(1):79-82
Chen, Y.H., Wang, W.H., Wang, Y.H., Lin, Z.Y., Wen, C.C., and Chern, C.Y. (2013) Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model. Molecules. 18(2):2052-2060
Wu, Y.C., Liu, C.Y., Chen, Y.H., Chen, R.F., Sun, T.T., Huang, C.J., and Wang, I.J. (2012) Blood vessel epicardial substance (BVES) regulates epidermal tight junction integrity through atypical protein kinase C. The Journal of biological chemistry. 287(47):39887-39897
Yeh, C.H., Liao, Y.F., Chang, C.Y., Tsai, J.N., Wang, Y.H., Cheng, C.C., Wen, C.C., and Chen, Y.H. (2012) Caffeine treatment disturbs the angiogenesis of zebrafish embryos. Drug and chemical toxicology. 35(4):361-365
Chen, Y.H., Yang, Z.S., Wen, C.C., Chang, Y.S., Wang, B.C., Hsiao, C.A., and Shih, T.L. (2012) Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae. Food Chemistry. 134(2):717-24
Tsai, I.T., Yang, Z.S., Lin, Z.Y., Wen, C.C., Cheng, C.C., and Chen, Y.H. (2012) Flavone is efficient to protect zebrafish fins from UV-induced damage. Drug and chemical toxicology. 35(3):341-346
Ding, Y.J., and Chen, Y.H. (2012) Developmental nephrotoxicity of aristolochic acid in a zebrafish model. Toxicology and applied pharmacology. 261(1):59-65
Chen, Y.H., Tsai, I.T., Wen, C.C., Wang, Y.H., Cheng, C.C., Hu, S.C., and Chen, Y.H. (2012) Fin reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos. Toxicology mechanisms and methods. 22(2):151-158
Lee, G.H., Chang, M.Y., Hsu, C.H., and Chen, Y.H. (2011) Essential roles of basic helix-loop-helix transcription factors, Capsulin and Musculin, during craniofacial myogenesis of zebrafish. Cellular and molecular life sciences : CMLS. 68(24):4065-78
Chen, Y.H., and Lin, J.S. (2011) A novel zebrafish mutant with wavy-notochord: An effective biological index for monitoring the copper pollution of water from natural resources. Environmental toxicology. 26(1):103-109
Chen, Y.H., Wen, C.C., Lin, C.Y., Chou, C.Y., Yang, Z.S., and Wang, Y.H. (2011) UV-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of broccoli and cauliflower extracts. Toxicology mechanisms and methods. 21(1):63-69
Chou, C.Y., Hsu, C.H., Wang, Y.H., Chang, M.Y., Chen, L.C., Cheng, S.C., and Chen, Y.H. (2011) Biochemical and structural properties of zebrafish Capsulin produced by Escherichia coli. Protein Expression and Purification. 75(1):21-27
Yang, D.C., Tsai, C.C., Liao, Y.F., Fu, H.C., Tsay, H.J., Huang, T.F., Chen, Y.H., and Hung, S.C. (2011) Twist controls skeletal development and dorsoventral patterning by regulating runx2 in zebrafish. PLoS One. 6(11):e27324
Pai, C.W., and Chen, Y.H. (2010) Transgenic expression of prothymosin alpha on zebrafish epidermal cells promotes proliferation and attenuates UVB-induced apoptosis. Transgenic Research. 19(4):655-665
Peng, H.C., Wang, Y.H., Wen, C.C., Wang, W.H., Cheng, C.C., and Chen, Y.H. (2010) Nephrotoxicity assessments of acetaminophen during zebrafish embryogenesis. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 151(4):480-486
Chen, Y.H., Wang, Y.H., Yu, T.H., Wu, H.J., and Pai, C.W. (2009) Transgenic zebrafish line with over-expression of Hedgehog on the skin: a useful tool to screen Hedgehog-inhibiting compounds. Transgenic Research. 18(6):855-864
Chen, Y.H., Lin, Y.T., and Lee, G.H. (2009) Novel and unexpected functions of zebrafish CCAAT box binding transcription factor (NF-Y) B subunit during cartilages development. Bone. 44(5):777-784
Chen, Y.H., Huang, Y.H., Wen, C.C., Wang, Y.H., Chen, W.L., Chen, L.C., and Tsay, H.J. (2008) Movement disorder and neuromuscular change in zebrafish embryos after exposure to caffeine. Neurotoxicology and teratology. 30(5):440-447
Wu, S.H., Chen, Y.H., Huang, F.L., Chang, C.H., Chang, Y.F., and Tsay, H.J. (2008) Multiple regulatory elements mediating neuronal-specific expression of zebrafish sodium channel gene, Scn8aa. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(9):2554-2565
Wang, Y.H., Li, C.K., Lee, G.H., Tsay, H.J., Tsai, H.J., and Chen, Y.H. (2008) Inactivation of zebrafish mrf4 leads to myofibril misalignment and motor axon growth disorganization. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(4):1043-1050
Chen, Y.H., Huang, F.L., Cheng, Y.C., Wu, C.J., Yang, C.N., and Tsay, H.J. (2008) Knockdown of zebrafish Nav1.6 sodium channel impairs embryonic locomotor activities. Journal of Biomedical Science. 15(1):69-78
Tsay, H.J., Wang, Y.H., Chen, W.L., Huang, M.Y., and Chen, Y.H. (2007) Treatment with sodium benzoate leads to malformation of zebrafish larvae. Neurotoxicology and teratology. 29(5):562-569
Chen, Y.H., Chen, W.L., Wang, Y.H., Huang, M.Y. and Chern, M.K. (2007) Spatiotemporal expression of zebrafish D -amino acid oxidase during early embryogenesis. Fish physiology and biochemistry. 33(1):73-80
Chen, Y.H., Wang, Y.H., Chang, M.Y., Lin, C.Y., Weng, C.W., Westerfield, M., and Tsai, H.J. (2007) Multiple upstream modules regulate zebrafish myf5 expression. BMC Developmental Biology. 7(1):1
Lin, C.Y., Yung, R.F., Lee, H.C., Chen, W.T., Chen, Y.H., and Tsai, H.J. (2006) Myogenic regulatory factors Myf5 and Myod function distinctly during craniofacial myogenesis of zebrafish. Developmental Biology. 299(2):594-608
Wang, Y.H., Chen, Y.H., Wu, T.N., Lin, Y.J., and Tsai, H.J. (2006) A keratin 18 transgenic zebrafish Tg(k18(2.9):RFP) treated with inorganic arsenite reveals visible overproliferation of epithelial cells. Toxicology letters. 163(3):191-197
Wang, Y.H., Chen, Y.H., Lin, Y.J., and Tsai, H.J. (2006) Spatiotemporal expression of zebrafish keratin 18 during early embryogenesis and the establishment of a keratin 18:RFP transgenic line. Gene expression patterns : GEP. 6(4):335-339
Wang, Y.H., Chen, Y.H., Lu, J.H., Lin, Y.J., Chang, M.Y., and Tsai, H.J. (2006) Epidermis-restricted expression of zebrafish cytokeratin II is controlled by a -141/+85 minimal promoter, and cassette -141/-111 is essential for driving the tissue specificity. Differentiation; research in biological diversity. 74(4):186-194
Lee, H.C., Huang, H.Y., Lin, C.Y., Chen, Y.H., and Tsai, H.J. (2006) Foxd3 mediates zebrafish myf5 expression during early somitogenesis. Developmental Biology. 290(2):359-372
Wang, Y.H., Chen, Y.H., Lu, J.H., and Tsai, H.J. (2005) A 23-amino Acid motif spanning the basic domain targets zebrafish myogenic regulatory factor myf5 into nucleolus. DNA and cell biology. 24(10):651-660
Lin, C.Y., Chen, Y.H., Lee, H.C., and Tsai, H.J. (2004) Novel cis-element in intron 1 represses somite expression of zebrafish myf-5. Gene. 334:63-72
Chen, Y.-H., Lee, H.-C., Liu, C.-F., Lin, C.-Y., and Tsai, H.-J. (2003) Novel regulatory sequence -82/-62 functions as a key element to drive the somite-specificity of zebrafish myf-5. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(1):41-50
Chen, Y.-H. and Tsai, H.-J. (2002) Treatment with Myf5-morpholino results in somite patterning and brain formation defects in zebrafish. Differentiation; research in biological diversity. 70(8):447-456
Wang, T.-M., Chen, Y.-H., Liu, C.-F., and Tsai, H.-J. (2002) Functional analysis of the proximal promoter regions of fish rhodopsin and myf-5 genes using transgenesis. Marine biotechnology (New York, N.Y.). 4(3):247-255
Chen, Y.-H., Liang, C.-T., and Tsai, H.-J. (2002) Expression, purification and DNA-binding activity of tilapia muscle-specific transcription factor, MyoD, produced in Escherichia coli. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 131(4):795-805
Chen, Y.-H., Lee, W.-C., Liu, C.-F., and Tsai, H.-J. (2001) Molecular structure, dynamic expression, and promoter analysis of zebrafish (Danio rerio) myf-5 gene. Genesis (New York, N.Y. : 2000). 29(1):22-35
Chen, Y.-H., Lee, W.-C., Cheng, C.-H., and Tsai, H.-J. (2000) Muscle regulatory factor gene: zebrafish (Danio rerio) myogenin cDNA. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 127(1):97-103