ZFIN ID: ZDB-LAB-060628-1
Jin Lab
PI/Director: Jin, Suk-Won
Contact Person: Jin, Suk-Won
Email: suk-won.jin@yale.edu
Address: Suk-Won Jin, Ph.D. Assistant Professor Dept. of Internal Medicine Section of Cardiovascular Medicine Yale University School of Medicine New Haven, CT, 06511
Country: United States
Phone: 203-737-2866
Line Designation: nc

Show all 9 genomic features

The main scientific interest of the laboratory is to understand how endothelial cells are specified and how these cells form vascular tubes.

Cardona-Costa, Jose Post-Doc Dunworth, William Post-Doc Schmitt, Chris Graduate Student
Woolls, Melissa Graduate Student Kang, Hyeseon Research Staff

Ka, J., Jin, S.W. (2021) Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases. Journal of lipid and atherosclerosis. 10:42-56
Ka, J., Kim, J.D., Pak, B., Han, O., Choi, W., Kim, H., Jin, S.W. (2020) Bone Morphogenetic Protein Signaling Restricts Proximodistal Extension of the Ventral Fin Fold. Frontiers in cell and developmental biology. 8:603306
Pak, B., Schmitt, C.E., Oh, S., Kim, J.D., Choi, W., Han, O., Kim, M., Kim, M.J., Ham, H.J., Kim, S., Huh, T.L., Kim, J.I., Jin, S.W. (2020) Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish. Biochemical and Biophysical Research Communications. 534:359-366
Pak, B., Schmitt, C.E., Choi, W., Kim, J.D., Han, O., Alsiö, J., Jung, D.W., Williams, D.R., Coppieters, W., Stainier, D.Y.R., Jin, S.W. (2020) Analyses of Avascular Mutants Reveal Unique Transcriptomic Signature of Non-conventional Endothelial Cells. Frontiers in cell and developmental biology. 8:589717
Kim, A.R., Kim, S.W., Lee, B.W., Kim, K.H., Kim, W.H., Seok, H., Lee, J.H., Um, J., Yim, S.H., Ahn, Y., Jin, S.W., Jung, D.W., Oh, W.K., Williams, D.R. (2020) Screening ginseng saponins in progenitor cells identifies 20(R)-ginsenoside Rh2 as an enhancer of skeletal and cardiac muscle regeneration. Scientific Reports. 10:4967
Karthik, S., Djukic, T., Kim, J.D., Zuber, B., Makanya, A., Odriozola, A., Hlushchuk, R., Filipovic, N., Jin, S.W., Djonov, V. (2019) Publisher Correction: Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development. Scientific Reports. 9:4152
Karthik, S., Djukic, T., Kim, J.D., Zuber, B., Makanya, A., Odriozola, A., Hlushchuk, R., Filipovic, N., Jin, S.W., Djonov, V. (2018) Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development. Scientific Reports. 8:9840
Peneyra, S.M., Cardona-Costa, J., White, J., Whipps, C.M., Riedel, E.R., Lipman, N.S., Lieggi, C. (2017) Transmission of Pseudoloma neurophilia in Laboratory Zebrafish (Danio rerio) When Using Mass Spawning Chambers and Recommendations for Chamber Disinfection. Zebrafish. 15(1):63-72
Hwangbo, C., Lee, H.W., Kang, H., Ju, H., Wiley, D.S., Papangeli, I., Han, J., Kim, J.D., Dunworth, W.P., Hu, X., Lee, S., El-Hely, O., Sofer, A., Pak, B., Peterson, L., Comhair, S., Hwang, E.M., Park, J.Y., Thomas, J.L., Bautch, V.L., Erzurum, S.C., Chun, H.J., Jin, S.W. (2017) Modulation of Endothelial BMPR2 Activity by VEGFR3 in Pulmonary Arterial Hypertension. Circulation. 135(23):2288-2298
Mouillesseaux, K.P., Wiley, D.S., Saunders, L.M., Wylie, L.A., Kushner, E.J., Chong, D.C., Citrin, K.M., Barber, A.T., Park, Y., Kim, J.D., Samsa, L.A., Kim, J., Liu, J., Jin, S.W., Bautch, V.L. (2016) Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6.. Nature communications. 7:13247
Kim, Y.S., Jeong, H.Y., Kim, A.R., Kim, W.H., Cho, H., Um, J., Seo, Y., Kang, W.S., Jin, S.W., Kim, M.C., Kim, Y.C., Jung, D.W., Williams, D.R., Ahn, Y. (2016) Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment. Scientific Reports. 6:30726
Reischauer, S., Stone, O.A., Villasenor, A., Chi, N., Jin, S.W., Martin, M., Lee, M.T., Fukuda, N., Marass, M., Witty, A., Fiddes, I., Kuo, T., Chung, W.S., Salek, S., Lerrigo, R., Alsiö, J., Luo, S., Tworus, D., Augustine, S.M., Mucenieks, S., Nystedt, B., Giraldez, A.J., Schroth, G.P., Andersson, O., Stainier, D.Y. (2016) Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 535:294-8
Cha, J.J., Park, Y., Yun, J., Kim, H.W., Park, C.J., Kang, G., Jung, M., Pak, B., Jin, S.W., Lee, J.H. (2016) Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers. BioMed Research International. 2016:8484217
So, J.H., Kim, J.D., Yoo, K.W., Kim, H.T., Jung, S.H., Choi, J.H., Lee, M.S., Jin, S.W., Kim, C.H. (2014) FIH-1, a Novel Interactor of Mindbomb, Functions as an Essential Anti-Angiogenic Factor during Zebrafish Vascular Development. PLoS One. 9:e109517
Kim, J.D., Lee, H.W., Jin, S.W. (2014) Diversity Is in My Veins: Role of Bone Morphogenetic Protein Signaling During Venous Morphogenesis in Zebrafish Illustrates the Heterogeneity Within Endothelial Cells. Arterioscler. Thromb. Vasc. Biol.. 34(9):1838-45
Kim, J.D., Jin, S.W. (2014) A Tale of Two Models: Mouse and Zebrafish as Complementary Models for Lymphatic Studies. Molecules and cells. 37(7):503-10
Sakurai, T., Woolls, M.J., Jin, S.W., Murakami, M., Simons, M. (2014) Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PLoS One. 9:e90736
Kim, J.D., Kang, Y., Kim, J., Papangeli, I., Kang, H., Wu, J., Park, H., Nadelmann, E., Rockson, S.G., Chun, H.J., and Jin, S.W. (2014) Essential role of apelin signaling during lymphatic development in zebrafish. Arterioscler. Thromb. Vasc. Biol.. 34(2):338-345
Dunworth, W.P., Cardona-Costa, J., Cagavi, E., Kim, J.D., Fischer, J.C., Meadows, S., Wang, Y., Cleaver, O., Qyang, Y., Ober, E.A., and Jin, S.W. (2014) Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos. Circulation research. 114(1):56-66
Nie, L., Guo, X., Esmailzadeh, L., Zhang, J., Asadi, A., Collinge, M., Li, X., Kim, J.D., Woolls, M., Jin, S.W., Dubrac, A., Eichmann, A., Simons, M., Bender, J.R., and Sadeghi, M.M. (2013) Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J. Clin. Invest.. 123(12):5082-97
Schmitt, C.E., Woolls, M.J., and Jin, S.W. (2013) Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish. Molecules and cells. 35(2):166-172
Kim, S.H., Schmitt, C.E., Woolls, M.J., Holland, M.B., Kim, J.D., and Jin, S.W. (2013) Vascular Endothelial Growth Factor Signaling Regulates the Segregation of Artery and Vein via ERK Activity during Vascular Development. Biochemical and Biophysical Research Communications. 430(4):1212-1216
Schmitt, C.E. (2013) Identification of Novel Transcription Factors Regulating Recovery of the Endothelial Lineage in Avascular Mutants. Ph.D. Thesis.
Woolls, M.J. (2013) Hemogenic Endothelium within the Zebrafish Caudal Hematopoietic Tissue illustrates the Common Ties of the Vascular and Hematopoietic Systems. Ph.D. Thesis.
Pi, X., Schmitt, C.E., Xie, L., Portbury, A.L., Wu, Y., Lockyer, P., Dyer, L.A., Moser, M., Bu, G., Flynn, E.J., Jin, S.W., and Patterson, C. (2012) An LRP1-Dependent Endocytic Mechanism Governs the Signaling Output of the BMP System in Endothelial Cells and in Angiogenesis. Circulation research. 111(5):564-574
Kim, J.D., Kang, H., Larrivée, B., Lee, M.Y., Mettlen, M., Schmid, S.L., Roman, B.L., Qyang, Y., Eichmann, A., and Jin, S.W. (2012) Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Developmental Cell. 23(2):441-448
Cardona-Costa, J., Pérez-Camps, M., and García-Ximénez, F. (2012) Somatic cells derived from haploid larvae are feasible as donors for nuclear transplant in zebrafish. Preliminary results. Zygote (Cambridge, England). 20(3):277-280
Schmitt, C.E., Holland, M.B., and Jin, S.W. (2012) Visualizing vascular networks in zebrafish: an introduction to microangiography. Methods in molecular biology (Clifton, N.J.). 843:59-67
Wiley, D.M., Kim, J.D., Hao, J., Hong, C.C., Bautch, V.L., and Jin, S.W. (2011) Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nature cell biology. 13(6):686-92
Francisco-Simão, M., Cardona-Costa, J., Pérez-Camps, M., and García-Ximénez, F. (2011) Ultraviolet radiation and handling medium osmolarity affect chimaerism success in zebrafish. Zygote (Cambridge, England). 19(1):67-70
Cardona-Costa, J., Pérez-Camps, M., and García-Ximénez, F. (2011) Electroactivation of zebrafish (Danio rerio) eggs. Spanish journal of agricultural research. 9(1):59-65
Francisco-Simão, M., Cardona-Costa, J., Perez Camps, M., and García-Ximénez, F. (2010) Ultraviolet Radiation Dose to be Applied in Recipient Zebrafish Embryos for Germ-line Chimaerism is Strain Dependent. Reproduction in domestic animals = Zuchthygiene. 45(6):1098-1103
Pérez-Camps, M., Cardona-Costa, J., and García-Ximénez, F. (2010) Transplantation of Adult Fibroblast Nuclei into the Central Region of Metaphase II Eggs Resulted in Mid-Blastula Transition Embryos. Zebrafish. 7(2):215-218
Cardona-Costa, J., Francisco-Simão, M., Pérez-Camps, M., and García-Ximénez, F. (2010) Micromanipulation medium osmolarity compromises zebrafish (Danio rerio) embryo and cell survival in chimaerism experiments. Zygote (Cambridge, England). 18(2):155-158
Pérez-Camps, M., Cardona-Costa, J., Francisco-Simao, M., and García-Ximénez, F. (2010) Definition of three somatic adult cell nuclear transplant methods in zebrafish (Danio rerio): before, during and after egg activation by sperm fertilization. Zygote (Cambridge, England). 18(1):33-39
Cardona-Costa, J., Francisco-Simão, M., and García-Ximénez, F. (2009) Can vitrified zebrafish blastomeres be used to obtain germ-line chimaeras?. Cryo letters. 30(6):422-428
Lee, C.Y., Vogeli, K.M., Kim, S.H., Chong, S.W., Jiang, Y.J., Stainier, D.Y., and Jin, S.W. (2009) Notch Signaling Functions as a Cell-Fate Switch between the Endothelial and Hematopoietic Lineages. Current biology : CB. 19(19):1616-1622
Bono-Mestre, C., Cardona-Costa, J., and García-Ximenez, F. (2009) Effects on cell viability of three zebrafish testicular cell or tissue cryopreservation methods. Cryo letters. 30(2):148-152
Cardona-Costa, J., Pérez-Camps, M., García-Ximénez, F., and Espinós, F.J. (2009) Effect of Gametes Aging on Their Activation and Fertilizability in Zebrafish (Danio rerio). Zebrafish. 6(1):93-95
Osborne, N., Brand-Arzamendi, K., Ober, E.A., Jin, S.W., Verkade, H., Holtzman, N.G., Yelon, D., and Stainier, D.Y. (2008) The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Current biology : CB. 18(23):1882-1888
Pérez-Camps, M., Francisco-Simão, M., Cardona-Costa, J., and García-Ximénez, F. (2008) Evaluation of presumptive caudal fin blastema cells as candidate donors in intrasecies zebrafish (Danio rerio) chimaeras. Spanish journal of agricultural research. 6(4):610-614
Cardona-Costa, J., and Garcia-Ximenez, F. (2007) Vitrification of zebrafish embryo blastomeres in microvolumes. Cryo letters. 28(4):303-310
Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y. (2007) A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Developmental Biology. 307(1):29-42
Scott, I.C., Masri, B., D'Amico, L.A., Jin, S.W., Jungblut, B., Wehman, A.M., Baier, H., Audigier, Y., and Stainier, D.Y. (2007) The G protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Developmental Cell. 12(3):403-413
Vogeli, K.M., Jin, S.W., Martin, G.R., and Stainier, D.Y. (2006) A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula. Nature. 443(7109):337-339
Cardona-Costa, J., Roig, J., Perez-Camps, M., and Garcia-Ximenez, F. (2006) Vitrification of caudal fin explants from zebrafish adult specimens. Cryo letters. 27(5):329-332
Jin, S.W., Beis, D., Mitchell, T., Chen, J.N., Stainier, D.Y. (2005) Cellular and molecular analyses of vascular tube and lumen formation in zebrafish. Development (Cambridge, England). 132(23):5199-5209
Beis, D., Bartman, T., Jin, S.W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.N., Stainier, D.Y., and Jungblut, B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (Cambridge, England). 132(18):4193-4204
Bree, R.T., McLoughlin, S., Jin, S.W., McMeel, O.M., Stainier, D.Y., Grealy, M., and Byrnes, L. (2005) nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafish. Biochemical and Biophysical Research Communications. 333(3):722-728
Qian, F., Zhen, F., Ong, C., Jin, S.W., Meng Soo, H., Stainier, D.Y., Lin, S., Peng, J., and Wen, Z. (2005) Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Developmental dynamics : an official publication of the American Association of Anatomists. 233(3):1163-1172
Parker, L.H., Schmidt, M., Jin, S.W., Gray, A.M., Beis, D., Pham, T., Frantz, G., Palmieri, S., Hillan, K., Stainier, D.Y., De Sauvage, F.J., Ye, W. (2004) The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature. 425(6984):754-758
Ober, E.A., Olofsson, B., Makinen, T., Jin, S.W., Shoji, W., Koh, G.Y., Alitalo, K., and Stainier, D.Y. (2004) Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. EMBO reports. 5(1):78-84