ZFIN ID: ZDB-GENE-990415-270
Gene Name: tumor protein p53
Gene Symbol: tp53
Previous Names: p53 (1), brp53, drp53, etID22686.5 (1), fb40d06, wu:fb40d06 (1), zgc:111919
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 85 figures from 65 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:111919]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, exocrine pancreas, eye, gill (all 21) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 83 Genotypes
Knockdown reagents: CRISPR1-tp53 (1), MO1-tp53, MO3-tp53 (1), MO4-tp53 (6), MO5-tp53 (1) (all 14) expand

Allele Type Mutagen Suppliers
hu888 Point Mutation ENU
la015599Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024884Tg Transgenic Insertion DNA
    la024885Tg Transgenic Insertion DNA
    la024886Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029070Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1114 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20404 Point Mutation ENU
    sa20405 Point Mutation ENU
    zdf1 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • zdf2 Point Mutation ENU
    zdf3 Point Mutation ENU
    zdf4 Point Mutation ENU
    zdf5 Point Mutation ENU
    zy7 Point Mutation ENU
    PHENOTYPE
    Data: 17 figures from 14 publications
    Observed in: angiogenesis, apoptotic process, eye, fin (all 23) expand
    DISEASE ASSOCIATED WITH tp53 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    adrenocortical carcinoma Adrenal cortical carcinoma 202300
    breast cancer Breast cancer 114480
    choroid plexus papilloma Choroid plexus papilloma 260500
    colorectal cancer Colorectal cancer 114500
    hepatocellular carcinoma Hepatocellular carcinoma 114550
    Li-Fraumeni syndrome Li-Fraumeni syndrome 151623
    osteosarcoma Osteosarcoma 259500
    pancreatic carcinoma Pancreatic cancer 260350
    basal cell carcinoma {Basal cell carcinoma 7} 614740
    malignant glioma {Glioma susceptibility 1} 137800
    Nasopharyngeal carcinoma 607107
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component intracellular (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 52)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002117 (1)
  • InterPro:IPR008967 (1)
  • InterPro:IPR010991 (1)
  • InterPro:IPR011615 (1)
  • InterPro:IPR012346 (1)
  • PROSITE:PS00348 (1)
  • Pfam:PF00870 (1)
  • Pfam:PF07710 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tp53-001 (1) 2204
    ncRNA tp53-002 (1) 802
    tp53-003 (1) 579
    tp53-004 (1) 748
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-tp53 (1), Ab2-tp53 (1), Ab3-tp53 (1), Ab4-tp53 (1), Ab6-tp53 (1) (all 8) expand
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tp53
    Tg(tp53-002:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    tp53 Contained in: [BAC] CH211-114C12 (1) (order this)
    tp53 Encodes: [EST] fb40d06 (1)
    [cDNA] MGC:111919 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001271820 (1) 2236 bp
    Genomic GenBank:AL928875 (1) 158038 bp
    Select Tool
    Polypeptide UniProtKB:G1K2L5 (1) 374 aa
    Sequence Clusters UniGene:75100 (1)
    Sequence Information (all 39)
    OTHER tp53 GENE PAGES
  • Gene:30590 (1)
  • VEGA:OTTDARG00000016232 (1)
  • Ensembl(Zv9):ENSDARG00000035559 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL SS
    Zebrafish tp53 5  
    Human TP53 17 (17p13.1)
  • OMIM:191170
  • Gene:7157
  • Mouse Trp53 11 ( 42.83 cM)
  • MGI:98834
  • Gene:22059
  • Orthology Details
    CITATIONS (692)