ZFIN ID: ZDB-GENE-990415-270
Gene Name: tumor protein p53
Gene Symbol: tp53
Previous Names: p53 (1), brp53, drp53, etID22686.5 (1), fb40d06, wu:fb40d06 (1), zgc:111919
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 100 figures from 73 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:111919]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  anatomical structure, brain, cerebellum, cerebellum nucleus (all 41) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
hu888 Point Mutation ENU
la015599Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024884Tg Transgenic Insertion DNA
    la024885Tg Transgenic Insertion DNA
    la024886Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029070Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1114 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20404 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20405 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zdf1 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • zdf2 Point Mutation ENU
    zdf3 Point Mutation ENU
    zdf4 Point Mutation ENU
    zdf5 Point Mutation ENU
    zju101 Small Deletion TALEN
    zy7 Point Mutation ENU
    Targeting reagents: CRISPR1-tp53 (1), CRISPR2-tp53 (1), CRISPR3-tp53 (1), CRISPR4-tp53 (1), MO1-tp53 (all 18) expand
    PHENOTYPE
    Data: 19 figures from 16 publications
    Observed in: angiogenesis, apoptotic process, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining (all 27) expand
    DISEASE ASSOCIATED WITH tp53 HUMAN ORTHOLOG 
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    adrenocortical carcinoma Adrenal cortical carcinoma 202300
    basal cell carcinoma {Basal cell carcinoma 7} 614740
    breast cancer Breast cancer 114480
    choroid plexus papilloma Choroid plexus papilloma 260500
    colon carcinoma Colorectal cancer 114500
    colorectal cancer Colorectal cancer 114500
    hepatocellular carcinoma Hepatocellular carcinoma 114550
    Li-Fraumeni syndrome Li-Fraumeni syndrome 151623
    malignant glioma {Glioma susceptibility 1} 137800
    nasopharynx carcinoma Nasopharyngeal carcinoma 607107
    osteosarcoma Osteosarcoma 259500
    pancreatic carcinoma Pancreatic cancer 260350
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component chromatin (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 53)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002117 (1)
  • InterPro:IPR008967 (1)
  • InterPro:IPR010991 (1)
  • InterPro:IPR011615 (1)
  • InterPro:IPR012346 (1)
  • PROSITE:PS00348 (1)
  • Pfam:PF00870 (1)
  • Pfam:PF07710 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tp53-001 (1) 2204
    ncRNA tp53-002 (1) 802
    tp53-003 (1) 579
    tp53-004 (1) 748
    GENE PRODUCT DESCRIPTION
    ANTIBODIES 
    Ab1-tp53 (1), Ab2-tp53 (1), Ab3-tp53 (1), Ab4-tp53 (1), Ab6-tp53 (1) (all 8) expand
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tp53
    Tg(tp53-002:GFP), Tg(tp53:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    tp53Contained in: [BAC] CH211-114C12 (1) (order this)
    tp53Encodes: [EST] fb40d06 (1)
    [cDNA] MGC:111919 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001271820 (1) 2236bp
    Genomic GenBank:AL928875 (1) 158038bp
    Select Tool
    Polypeptide UniProtKB:G1K2L5 (1) 374aa
    Sequence Clusters UniGene:75100 (1)
    Sequence Information (all 42)
    OTHER tp53 GENE PAGES 
  • Gene:30590 (1)
  • VEGA:OTTDARG00000016232 (1)
  • Ensembl(GRCz10):ENSDARG00000035559 (1)
  • ORTHOLOGY for tp53 (Chr: 5) 
    Species Symbol Chromosome Accession # Evidence
    Human TP53 17
  • Gene:7157
  • OMIM:191170
  • HGNC:11998
  • Amino acid sequence comparison (6)
    Conserved genome location (synteny) (2)
    Other (1)
    Mouse Trp53 11
  • MGI:98834
  • Gene:22059
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (816)