Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-990415-270
Gene Name: tumor protein p53
Gene Symbol: tp53
Previous Names: brp53, drp53, p53 (1), etID22686.5 (1), fb40d06, wu:fb40d06 (1), zgc:111919
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 78 figures from 58 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:111919]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, exocrine pancreas, eye, gill (all 19) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 80 genotypes
Alleles: hu888, la015599Tg, la024884Tg, la024885Tg, la024886Tg (all 15) expand
Knockdown reagents: MO1-tp53, MO3-tp53 (1), MO4-tp53 (6), MO5-tp53 (1), MO6-tp53 (1) (all 12) expand
PHENOTYPE
Data: 15 figures from 12 publications
Observed in: angiogenesis, apoptotic process, eye, gill (all 19) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Adrenal cortical carcinoma 202300
Breast cancer 114480
Choroid plexus papilloma 260500
Colorectal cancer 114500
Hepatocellular carcinoma 114550
Li-Fraumeni syndrome 151623
Nasopharyngeal carcinoma 607107
Osteosarcoma 259500
Pancreatic cancer 260350
{Basal cell carcinoma 7} 614740
{Glioma susceptibility 1} 137800
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of transcription, DNA-templated (more)
Cellular Component intracellular (more)
Molecular Function protein binding (more)
GO Terms (all 48)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002117 (1)
  • InterPro:IPR008967 (1)
  • InterPro:IPR010991 (1)
  • InterPro:IPR011615 (1)
  • InterPro:IPR012346 (1)
  • PROSITE:PS00348 (1)
  • Pfam:PF00870 (1)
  • Pfam:PF07710 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tp53-001 (1) 2204
    ncRNA tp53-002 (1) 802
    tp53-003 (1) 579
    tp53-004 (1) 748
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-tp53 (1), Ab2-tp53 (1), Ab3-tp53 (1), Ab4-tp53 (1), Ab6-tp53 (1) (all 8) expand
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tp53 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    tp53 Contained in: [BAC] CH211-114C12 (1) (order this)
    tp53 Encodes: [EST] fb40d06 (1)
    [cDNA] MGC:111919 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001271820 (1) 2236 bp
    Genomic GenBank:AL928875 (1) 158038 bp
    Select Tool
    Polypeptide UniProtKB:G1K2L5 (1) 374 aa
    Sequence Clusters UniGene:75100 (1)
    Sequence Information (all 39)
    OTHER tp53 GENE PAGES
  • Gene:30590 (1)
  • VEGA:OTTDARG00000016232 (1)
  • Ensembl(Zv9):ENSDARG00000035559 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL SS
    Zebrafish tp53 5  
    Human TP53 17 (17p13.1)
  • OMIM:191170
  • Gene:7157
  • Mouse Trp53 11 ( 42.83 cM)
  • MGI:98834
  • Gene:22059
  • Orthology Details
    CITATIONS (611)