Gene

tp53

ID
ZDB-GENE-990415-270
Name
tumor protein p53
Symbol
tp53 Nomenclature History
Previous Names
  • p53 (1)
  • brp53
  • drp53
  • etID22686.5 (1)
  • fb40d06
  • wu:fb40d06 (1)
  • zgc:111919
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification and transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification. Acts upstream of or within several processes, including hemopoiesis; intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; head; hematopoietic system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; cancer; and malignant peripheral nerve sheath tumor. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
194 figures from 156 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
39 figures from 32 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tp53 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adrenocortical carcinoma Alliance {Adrenocortical carcinoma, pediatric} 202300
breast cancer Alliance Breast cancer, somatic 114480
choroid plexus papilloma Alliance {Choroid plexus papilloma} 260500
colorectal cancer Alliance {Colorectal cancer} 114500
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
Li-Fraumeni syndrome 1 Alliance Li-Fraumeni syndrome 151623
nasopharynx carcinoma Alliance Nasopharyngeal carcinoma, somatic 607107
osteosarcoma Alliance {Osteosarcoma} 259500
pancreatic carcinoma Alliance Pancreatic cancer, somatic 260350
Bone marrow failure syndrome 5 618165
{Basal cell carcinoma 7} 614740
{Glioma susceptibility 1} 137800
Associated With tp53 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR010991 p53, tetramerisation domain
Domain IPR011615 p53, DNA-binding domain
Family IPR002117 p53 tumour suppressor family
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR036674 p53-like tetramerisation domain superfamily
Domain Details Per Protein
Protein Length p53, DNA-binding domain p53-like tetramerisation domain superfamily p53-like transcription factor, DNA-binding p53/RUNT-type transcription factor, DNA-binding domain superfamily p53, tetramerisation domain p53 tumour suppressor family
UniProtKB:G1K2L5 374
UniProtKB:A0A2R8Q2E9 289
UniProtKB:Q502Q9 374
UniProtKB:A0A0B4VEV8 294
UniProtKB:P79734 373
UniProtKB:A0A2R8RHX5 374
UniProtKB:A0A0B4VEY6 289
UniProtKB:A0A2R8RTB8 294
UniProtKB:B0R0M3 369
UniProtKB:A0A0B4VFS7 261
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tp53 monoclonal Mouse
  • IHC
  • WB
3
Ab10-tp53 monoclonal Mouse
  • IHC
  • WB
8
Ab11-tp53 monoclonal IgG Mouse
  • WB
Abcam plc
11
Ab2-tp53 monoclonal IgG1 Mouse
  • IHC
  • WB
3
Ab6-tp53 monoclonal Mouse
  • WB
2
Ab7-tp53 polyclonal Rabbit
  • WB
AnaSpec
7
Ab3-tp53 monoclonal IgG1 Mouse
  • WB
6
Ab4-tp53 polyclonal Rabbit
1
Ab9-tp53 polyclonal Rabbit
1
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations