Gene
mtnr1aa
- ID
- ZDB-GENE-990415-155
- Name
- melatonin receptor 1A a
- Symbol
- mtnr1aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in female organism and male organism. Orthologous to human MTNR1A (melatonin receptor 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Melatonin receptor 1A/1B | Melatonin receptor family |
|---|---|---|---|---|---|---|
| UniProtKB:P51046 | InterPro | 350 | ||||
| UniProtKB:B2GP09 | InterPro | 350 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
mtnr1aa-202
(1)
|
Ensembl | 776 nt | ||
| mRNA |
mtnr1aa-201
(1)
|
Ensembl | 1,806 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-161C21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-13D23 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110628 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191341 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131393 (1) | 1832 nt | ||
| Genomic | GenBank:CR753839 (1) | 169064 nt | ||
| Polypeptide | UniProtKB:B2GP09 (1) | 350 aa |
- Pang, M.Z., Li, H.X., Dai, X.Q., Wang, X.B., Liu, J.Y., Shen, Y., Xu, X., Zhong, Z.M., Wang, H., Liu, C.F., Wang, F. (2024) Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson's Disease. Neuroscience Bulletin. 40(12):1901-1914
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
- D'Agostino, Y., Frigato, E., Noviello, T.M.R., Toni, M., Frabetti, F., Cigliano, L., Ceccarelli, M., Sordino, P., Cerulo, L., Bertolucci, C., D'Aniello, S. (2022) Loss of circadian rhythmicity in bdnf knockout zebrafish larvae. iScience. 25:104054
- Lutfi, E., Basili, D., Falcinelli, S., Morillas, L., Carnevali, O., Capilla, E., Navarro, I. (2021) The probiotic Lactobacillus rhamnosus mimics the dark-driven regulation of appetite markers and melatonin receptors' expression in zebrafish (Danio rerio) larvae: Understanding the role of the gut microbiome. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 256:110634
- Sua-Cespedes, C.D., David, D.D., Souto-Neto, J.A., Lima, O.G., Moraes, M.N., de Assis, L.V.M., Castrucci, A.M.L. (2021) Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio. Frontiers in Physiology. 12:707067
- Li, Y., Lv, Y., Bian, C., You, X., Shi, Q. (2020) Molecular evolution of melatonin receptor genes (mtnr) in vertebrates and its shedding light on mtnr1c. Gene. 769:145256
- Maugars, G., Nourizadeh-Lillabadi, R., Weltzien, F.A. (2020) New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Frontiers in endocrinology. 11:538196
- Loganathan, K., Moriya, S., Parhar, I.S. (2019) Diurnal Rhythm of trek2a Expression is Associated with Diurnal Rhythm of gnrh3 Expression in Zebrafish. Zoological science. 36:167-171
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Loganathan, K., Moriya, S., Parhar, I.S. (2018) Trek2a regulates gnrh3 expression under control of melatonin receptor Mt1 and α2-adrenoceptor.. Biochemical and Biophysical Research Communications. 496(3):927-933
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