PUBLICATION
Diurnal Rhythm of trek2a Expression is Associated with Diurnal Rhythm of gnrh3 Expression in Zebrafish
- Authors
- Loganathan, K., Moriya, S., Parhar, I.S.
- ID
- ZDB-PUB-190524-8
- Date
- 2019
- Source
- Zoological science 36: 167-171 (Journal)
- Registered Authors
- Keywords
- diurnal rhythm, gnrh3, mt1, reproduction, trek2a
- MeSH Terms
-
- Animals
- Circadian Rhythm/genetics*
- Circadian Rhythm/physiology
- Gene Expression Regulation/physiology
- Gonadotropin-Releasing Hormone/genetics
- Gonadotropin-Releasing Hormone/metabolism*
- Kisspeptins/metabolism
- Male
- Potassium Channels, Tandem Pore Domain/genetics
- Potassium Channels, Tandem Pore Domain/metabolism*
- Pyrrolidonecarboxylic Acid/analogs & derivatives*
- Pyrrolidonecarboxylic Acid/metabolism
- Real-Time Polymerase Chain Reaction
- Receptors, Melatonin/genetics
- Receptors, Melatonin/metabolism
- Zebrafish/genetics
- Zebrafish/metabolism*
- PubMed
- 31120653 Full text @ Zool. Sci.
Citation
Loganathan, K., Moriya, S., Parhar, I.S. (2019) Diurnal Rhythm of trek2a Expression is Associated with Diurnal Rhythm of gnrh3 Expression in Zebrafish. Zoological science. 36:167-171.
Abstract
The two-pore domain potassium ion (K + ) channel-related K + (TREK) channel and melatonin receptors play roles in the regulation of reproduction in zebrafish. Since reproduction is regulated by diurnal rhythms, the TREK family and melatonin receptors may exhibit diurnal rhythms in expression. In this study, we aimed to investigate diurnal variations of the gene expressions of TREK family and melatonin receptors and their associations with kisspeptin and gonadotrophin-releasing hormone (GnRH). Diurnal variations of trek1b, trek2a, trek2b, mt1, mt2, mel1a, kiss2 and gnrh3 expressions were examined by real-time PCR. For reproduction-related genes, kiss2 and gnrh3 exhibited diurnal rhythms. trek2a revealed a diurnal rhythm in the TREK family. mt2 and mel1c exhibited diurnal rhythms in the melatonin receptors. Since Trek2a regulates gnrh3 expression, the diurnal rhythm of gnrh3 expression suggests to be regulated by the diurnal rhythm of trek2a expression.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping