Gene
stat3
- ID
- ZDB-GENE-980526-68
- Name
- signal transducer and activator of transcription 3 (acute-phase response factor)
- Symbol
- stat3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; embryonic morphogenesis; and neuron development. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blastomere; bone tissue; epidermal superficial stratum; head; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 63 figures from 39 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55197 (9 images)
- eu734 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hyper IgE recurrent infection syndrome 1 | Alliance | Hyper-IgE syndrome 1, autosomal dominant, with recurrent infections | 147060 |
| Autoimmune disease, multisystem, infantile-onset, 1 | 615952 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR013799 | STAT transcription factor, protein interaction |
| Domain | IPR013800 | STAT transcription factor, all-alpha domain |
| Domain | IPR013801 | STAT transcription factor, DNA-binding |
| Domain | IPR035855 | STAT3, SH2 domain |
| Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
| Family | IPR001217 | Transcription factor STAT |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012345 | STAT transcription factor, DNA-binding, N-terminal |
| Homologous_superfamily | IPR015988 | STAT transcription factor, coiled coil |
| Homologous_superfamily | IPR036535 | STAT transcription factor, N-terminal domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT3, SH2 domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BB24 | InterPro | 821 | ||||||||||||
| UniProtKB:A0A8M2BAX1 | InterPro | 801 | ||||||||||||
| UniProtKB:A0A8M2BBA1 | InterPro | 753 | ||||||||||||
| UniProtKB:O93599 | InterPro | 806 | ||||||||||||
| UniProtKB:A0A0R4IGF2 | InterPro | 738 | ||||||||||||
| UniProtKB:Q6NV46 | InterPro | 786 |
Interactions and Pathways
Plasmids
No data available