ZFIN ID: ZDB-GENE-980526-68
Gene Name: signal transducer and activator of transcription 3 (acute-phase response factor)
Gene Symbol: stat3
Sequence Ontology ID : SO:0000704

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Previous Names: z-Stat3 (1), wu:fc15d02 (1), wu:fl59g06 (1)

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Location: Chr: 3 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have DNA binding activity and DNA-binding activity transcription factor activity; involved in several processes, including JAK-STAT cascade, animal organ development, and generation of  ...
GENE EXPRESSION
All Expression Data: 45 figures from 21 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [MGC:55197]
  7 figures (13 images) from Thisse et al., 2005 [eu734]
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb211 Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • ihb212 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • sa938 Point Mutation Unknown Splice Site ENU
    sa10162 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12185 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15744 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16856 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • stl27 Small Deletion Exon 5 Frameshift, Premature Stop TALEN
    stl28 Small Deletion Exon 5 Frameshift, Premature Stop TALEN
    Targeting reagents:
    PHENOTYPE
    Data: 12 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH stat3 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Job's syndrome Hyper-IgE recurrent infection syndrome 147060
    Autoimmune disease, multisystem, infantile-onset, 1 615952
    DISEASE ASSOCIATED WITH stat3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regeneration (more)
    Cellular Component cytoplasm (more)
    Molecular Function DNA binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000980 (1)
  • InterPro:IPR001217 (1)
  • InterPro:IPR008967 (1)
  • InterPro:IPR012345 (1)
  • InterPro:IPR013799 (1)
  • InterPro:IPR013800 (1)
  • InterPro:IPR013801 (1)
  • InterPro:IPR015988 (1)
  • InterPro:IPR035855 (1)
  • InterPro:IPR036535 (1)
  • InterPro:IPR036860 (1)
  • PROSITE:PS50001 (1)
  • Pfam:PF00017 (1)
  • Pfam:PF01017 (1)
  • Pfam:PF02864 (1)
  • Pfam:PF02865 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA stat3-003 (1) 2717
    mRNA stat3-201 (1) 2742
    stat3-202 (1) 3055
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM stat3
    MARKER RELATIONSHIPS
    stat3Contained in: [BAC] CH211-209D14 (1) (order this)
    stat3Encodes: [EST] eu734 (1), fc15d02 (1), fl59g06 (1)
    [cDNA] MGC:55197 (1) (order this), MGC:85598 (1) (order this), MGC:193054 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131479 (1) 3071bp
    Genomic GenBank:CR847978 (1) 194409bp
    Select Tool
    Polypeptide UniProtKB:C0SPC7 (1) 806aa
    Sequence Clusters UniGene:132860 (1)
    Sequence Information (all 48)
    OTHER stat3 GENE PAGES
  • Alliance (1)
  • Gene:30767 (1)
  • VEGA:OTTDARG00000033676 (1)
  • Ensembl(GRCz11):ENSDARG00000022712 (2)
  • ORTHOLOGY for stat3 (Chr: 3)
    CITATIONS (102)