ZFIN ID: ZDB-GENE-980526-68
Gene Name: signal transducer and activator of transcription 3 (acute-phase response factor)
Gene Symbol: stat3    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: z-Stat3 (1), wu:fc15d02 (1), wu:fl59g06 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; cardiac muscle tissue regeneration; and generation of neurons. Predicted to localize to cytosol and nucleus. Is expressed in blastomere; epidermal superficial stratum; head; immature eye; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; carcinoma (multiple); hyper IgE recurrent infection syndrome 1; inflammatory bowel disease (multiple); and reproductive organ cancer (multiple). Orthologous to human STAT3 (signal transducer and activator of transcription 3).
Genome Resources: Alliance (1),  Gene:30767 (1),  Ensembl(GRCz11):ENSDARG00000022712 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb211 Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb212 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa938 Point Mutation Unknown Splice Site ENU
    sa10162 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12185 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15744 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16856 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • stl27 Small Deletion Exon 5 Frameshift, Premature Stop TALEN
    stl28 Indel Exon 5 Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-stat3 1
    CRISPR2-stat3
    2
    CRISPR3-stat3
    1
    MO1-stat3 N/A 8
    MO2-stat3 N/A 2
    MO3-stat3 N/A 4
    MO4-stat3 N/A 1
    TALEN1-stat3 1
    DISEASE ASSOCIATED WITH stat3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hyper IgE recurrent infection syndrome 1 Alliance Hyper-IgE recurrent infection syndrome 147060
    Autoimmune disease, multisystem, infantile-onset, 1 615952
    DISEASE ASSOCIATED WITH stat3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regeneration (more)
    Cellular Component cytoplasm (more)
    Molecular Function DNA binding (more)
    GO Terms (all 32)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA stat3-201 (1)    Ensembl 2742
    stat3-202 (1)    Ensembl 3055
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab3-stat3 polyclonal Rabbit IHC, WB 6
    Ab7-stat3 polyclonal Rabbit WB AnaSpec
    2
    Ab1-stat3 monoclonal IgG1 Mouse IHC, WB MBL International
    8
    Ab4-stat3 polyclonal Rabbit AnaSpec
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM stat3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(7xstat3-hsv.ul23:egfp) stat3 EGFP Danio rerioHerpes simplex virus 0 1
    Tg(actb2:LOXP-DsRed-STOP-LOXP-dnstat3-GFP) actb2 DsRedGFPstat3 Danio rerio 1 4
    Tg(gfap:stat3-EGFP) gfap EGFPstat3 Danio rerio 1 5
    MARKER RELATIONSHIPS
    stat3 Contained in: [BAC] CH211-209D14 (1)
    stat3 Encodes: [EST] eu734 (1), fc15d02 (1), fl59g06 (1)
    [cDNA] MGC:55197 (1), MGC:85598 (1), MGC:193054 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131479 (1) 3071 nt
    Genomic GenBank:CR847978 (1) 194409 nt
    Select Tool
    Polypeptide UniProtKB:C0SPC7 (1) 806 aa
    Sequence Information (all 47)
    ORTHOLOGY for stat3 ( Chr: 3 )
    CITATIONS (113)